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New Geriatrics and Gerontology Study Findings Have Been Reported from Department of Microbiology (STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases)

Genomics & Genetics Weekly

11-09-18

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on Aging Research - Geriatrics and Gerontology is the subject of a report. According to news reporting out of Berlin, Germany, by NewsRx editors, research stated, "Aging is a multifactorial process driven by several conditions. Among them, inflamm-aging is characterized by chronic low-grade inflammation driving aging-related diseases."

Our news journalists obtained a quote from the research from the Department of Microbiology, "The aged immune system is characterized by the senescence-associated secretory phenotype, resulting in the release of proinflammatory cytokines contributing to inflamm-aging. Another possible mechanism resulting in inflamm-aging could be the increased release of danger-associated molecular patterns (DAMPs) by increased cell death in the elderly, leading to a chronic low-grade inflammatory response. Several pattern recognition receptors of the innate immune system are involved in recognition of DAMPs. The DNA-sensing cGAS-STING pathway plays a pivotal role in combating viral and bacterial infections and recognizes DNA released by cell death during the process of aging, which in turn may result in increased inflamm-aging. The aim of this study was to investigate whether a variation within the STING gene with known impaired function may be associated with protection from aging-related diseases by decreasing the process of inflamm-aging. STING (Tmem173) R293Q was genotyped in a cohort of 3,397 aged subjects (65-103 years). The distribution of the variant allele in healthy subjects and subjects suffering from aging-associated diseases was compared by logistic regression analysis. We show here that STING 293Q allele carriers were protected from aging-associated diseases (OR=0.823, p=0.038). This effect was much stronger in the subgroup of subjects suffering from chronic lung diseases (OR=0.730, p=0.009)."

According to the news editors, the research concluded: "Our results indicate that decreased sensitivity of the innate immune receptors is associated with healthy aging, most likely due to a decreased process of inflamm-aging."

For more information on this research see: STING SNP R293Q Is Associated with a Decreased Risk of Aging-Related Diseases. Gerontology, 2018;():1-10. (Karger - www.karger.com/; Gerontology - content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224091)

Our news journalists report that additional information may be obtained by contacting L. Hamann, Dept. of Microbiology, Infectious Diseases and Immunology, Charite - University Medical Center, Berlin, Germany. Additional authors for this research include J.S. Ruiz-Moreno, M. Szwed, M. Mossakowska, L. Lundvall, R.R. Schumann, B. Opitz and M. Puzianowska-Kuznicka (see also Aging Research - Geriatrics and Gerontology).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1159/000492972. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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