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Study Findings from A. Ishigami et al Provide New Insights into Vitamins (Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage)

Genomics & Genetics Weekly


By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Diet and Nutrition - Vitamins. According to news reporting originating from Tokyo, Japan, by NewsRx correspondents, research stated, "Several studies have reported the effects of vitamin C (L-ascorbic acid, AA) on ultraviolet B (UVB)-induced cell damage using cultured keratinocytes. However, the epidermis consists of multiple cell layers, and the effect of AA on UVB-induced damage to the human epidermis remains unclear."

Our news editors obtained a quote from the research, "Therefore, we investigated the effect of AA on UVB-induced skin damage using reconstituted human epidermis. The reconstituted human epidermal surface was treated with 100 and 500 mM AA and cultured for 3 h before (pre-AA treatment) or after (post-AA treatment) 120 mJ/cm(2) UVB irradiation. Preand post-AA treatments of the epidermal surface suppressed UVB-induced cell death, apoptosis, DNA damage, reactive oxygen species (ROS) production, and the inflammatory response by downregulating tumour necrosis factor-alpha (TNF-alpha) expression and release. Moreover, the pre-AA treatment was more effective at preventing UVB-induced skin damage than the post-AA treatment."

According to the news editors, the research concluded: "In summary, pre-and post-AA treatments of the epidermis prevent UVB-induced damage."

For more information on this research see: Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage. Scientific Reports, 2018;8():557-568. Scientific Reports can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)

The news editors report that additional information may be obtained by contacting A. Ishigami, Tokyo Metropolitan Inst Gerontol, Mol Regulat Aging, Tokyo 1730015, Japan. Additional authors for this research include T. Funakoshi, Y. Sato, N. Saito, H. Ohsawa, K. Kurita, K. Nagata, M. Yoshida and S. Kawashima (see also Diet and Nutrition - Vitamins).

(Our reports deliver fact-based news of research and discoveries from around the world.)

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