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New Pain Findings from University of Florence Outlined (Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo)

Drug Week

12-07-18

By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Neurologic Manifestations - Pain. According to news reporting originating from Florence, Italy, by NewsRx correspondents, research stated, "The beneficial effects of isothiocyanate-based compounds, as well as their safety, have been shown in neuropathological disorders, such as neuropathic pain. Aim of the present work was to study the efficacy of the glucosinolate glucoraphanin (GRA) and the derived isothiocyanate sulforaphane (SFN), secondary metabolites occurring exclusively in Brassicales, on chemotherapy-induced neuropathic pain."

Our news editors obtained a quote from the research from the University of Florence, "Mice were repeatedly treated with oxaliplatin (2.4 mg kg(-1) ip) for 14 days to induce neuropathic pain. GRA and SFN effects were evaluated after a single administration on Day 15 or after a daily repeated oral and subcutaneous treatment starting from the first day of oxaliplatin injection until the 14(th) day. Single subcutaneous and oral administrations of GRA (4.43-119.79 mu mol kg(-1)) or SFN (1.33-13.31 mu mol kg(-1)) reduced neuropathic pain in a dose-dependent manner. The repeated administration of GRA and SFN (respectively 13.31 and 4.43 mu mol kg(-1)) prevented the chemotherapy-induced neuropathy. The co-administration of GRA and SFN in mixture with the H2S binding molecule, haemoglobin, abolished their pain-relieving effect, which was also reverted by pretreating the animals with the selective blocker of Kv7 potassium channels, XE991."

According to the news editors, the research concluded: "GRA and SFN reduce neuropathic pain by releasing H2S and modulating Kv7 channels and show a protective effect on the chemotherapy-induced neuropathy."

For more information on this research see: Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo. Phytotherapy Research, 2018;32(11):2226-2234. Phytotherapy Research can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Phytotherapy Research - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1573)

The news editors report that additional information may be obtained by contacting L.D. Mannelli, University of Florence, Dept. of Neurosci, Psychol Drug Res & Child Hlth Neurofarba Pharmaco, I-50139 Florence, Italy. Additional authors for this research include L. Micheli, E. Trallori, V. Citi, A. Martelli, L. Testai, G.R. De Nicola, R. Iori, V. Calderone, C. Ghelardini and E. Lucarini (see also Neurologic Manifestations - Pain).

(Our reports deliver fact-based news of research and discoveries from around the world.)

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