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Data on Neurodegeneration Reported by A.R. Mendelsohn and Colleagues (Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration)

Genomics & Genetics Weekly

01-11-19

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in Neurology - Neurodegeneration. According to news reporting from Sunnyvale, California, by NewsRx journalists, research stated, "Neuroinflammation is thought to play a key role in the progression of neurodegenerative disease such as Alzheimer's disease (AD). Given the apparent nexus of inflammatory disease with the secretory-associated senescence phenotype (SASP) of cellular senescence, two reports found that tau-mediated neurodegeneration involves induction of senescence in astrocytes, microglia, and possibly even neurons."

The news correspondents obtained a quote from the research, "Elimination of senescent cells by pharmacologically induced genetic ablation or by senolytic drugs blocks progression of mutant human tau-mediated neurodegeneration in mice. This work suggests a working hypothesis through which tau activation leads to senescence and then tau propagation throughout the brain is supported by, and neurotoxicity is caused by, SASP, forming a pathological positive feedback loop."

According to the news reporters, the research concluded: "Although preliminary, these data suggest that the development of senolytics for AD and other tauopathies, especially early disease, and possibly senomodulatory drugs for later stage neurodegenerative disease may prove fruitful."

For more information on this research see: Cellular Senescence as the Key Intermediate in Tau-Mediated Neurodegeneration. Rejuvenation Research, 2018;21(6):572-579. Rejuvenation Research can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Rejuvenation Research - www.liebertpub.com/overview/rejuvenation-research/127/)

Our news journalists report that additional information may be obtained by contacting A.R. Mendelsohn, Regenerat Sci Inst, Sunnyvale, CA 94089, United States (see also Neurology - Neurodegeneration).

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1089/rej.2018.2155. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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