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Researchers from School of Public Health Describe Findings in Geriatrics and Gerontology (Telomere Length and All-cause Mortality: a Meta-analysis)

Health & Medicine Daily

03-15-19

2019 MAR 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Investigators publish new report on Aging Research - Geriatrics and Gerontology. According to news originating from Hubei, People’s Republic of China, by NewsRx correspondents, research stated, “Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL) and all-cause mortality remain inconsistent.”

Funders for this research include Erik Ronnberg award for scientific studies on aging and age-related diseases, National Natural Science Foundation of China, Karolinska Institutet Delfinansiering (KID), Loo and Hans Osterman Foundation, Foundation for geriatric diseases, Magnus Bergwall foundation, Foundation for Gamla Tjanarinnor, Karolinska Institutet (Strategic Research Area in Epidemiology and Senior Researcher Award), Swedish Research Council, Swedish Council for Working Life and Social Research (FORTE), China Scholarship Council (State Scholarship Fund 2017).

Our news journalists obtained a quote from the research from the School of Public Health, “In the present study, a meta-analysis was performed using published cohort studies and un-published data from the Swedish Twin Registry (STR). Twenty-five studies were included: four STR cohorts (12,083 individuals with 2517 deaths) and 21 published studies. In the STR studies, one standard deviation (SD) decrement of leukocyte TL corresponded to 13% increased all-cause mortality risk (95% confidence interval [CI]: 7%-19%); individuals in the shortest TL quarter had 44% higher hazard (95% CI: 27%-63%) than those in the longest quarter. Meta-analysis of all eligible studies (121,749 individuals with 21,763 deaths) revealed one SD TL decrement-associated hazard ratio of 1.09 (95% CI: 1.06-1.13); those in the shortest TL quarter had 26% higher hazard (95% CI: 15%-38%) compared to the longest quarter, although between-study heterogeneity was observed. Analyses stratified by age indicated that the hazard ratio was smaller in individuals over 80 years old. In summary, short telomeres are associated with increased all-cause mortality risk in the general population.”

According to the news editors, the research concluded: “However, TL measurement techniques and age at measurement contribute to the heterogeneity of effect estimation.”

For more information on this research see: Telomere Length and All-cause Mortality: a Meta-analysis. Ageing Research Reviews, 2018;48():11-20. Ageing Research Reviews can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Ageing Research Reviews - http://www.journals.elsevier.com/ageing-research-reviews/)

The news correspondents report that additional information may be obtained from Q. Wang, Huazhong Univ Sci & Techol, Sch Public Hlth, Dept. of Epidemiol & Biostat, Tongji Med College, Wuhan 430030, Hubei, People’s Republic of China. Additional authors for this research include Y.Q. Zhan, N.L. Pedersen, F. Fang and S. Hagg.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.arr.2018.09.002. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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