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Studies from University of Louisville Reveal New Findings on Malaria (Differential Sensitivity To Plasmodium Yoelii Infection In C57bl/6 Mice Impacts Gut-liver Axis Homeostasis)

Zika & Mosquito Daily

04-17-19

2019 APR 16 (NewsRx) -- By a News Reporter-Staff News Editor at Zika & Mosquito Daily -- Investigators publish new report on Mosquito-Borne Diseases - Malaria. According to news originating from Louisville, Kentucky, by NewsRx correspondents, research stated, “Experimental models of malaria have shown that infection with specific Plasmodium species in certain mouse strains can transiently modulate gut microbiota and cause intestinal shortening, indicating a disruption of gut homeostasis. Importantly, changes in gut homeostasis have not been characterized in the context of mild versus severe malaria.”

Financial support for this research came from National Institute of Allergy and Infectious Disease of the National Institutes of Health.

Our news journalists obtained a quote from the research from the University of Louisville, “We show that severe Plasmodium infection in mice disrupts homeostasis along the gut-liver axis in multiple ways compared to mild infection. High parasite burden results in a larger influx of immune cells in the lamina propria and mice with high parasitemia display specific meta bolomic profiles in the ceca and plasma during infection compared to mice with mild parasitemia. Liver damage was also more pronounced and longer lasting during severe infection, with concomitant changes in bile acids in the gut. Finally, severe Plasmodium infection changes the functional capacity of the microbiota, enhancing bacterial motility and amino acid metabolism in mice with high parasite burden compared to a mild infection.”

According to the news editors, the research concluded: “Taken together, Plasmodium infections have diverse effects on host gut homeostasis relative to the severity of infection that may contribute to enteric bacteremia that is associated with malaria.”

For more information on this research see: Differential Sensitivity To Plasmodium Yoelii Infection In C57bl/6 Mice Impacts Gut-liver Axis Homeostasis. SCIENTIFIC REPORTS, 2019;9():. SCIENTIFIC REPORTS can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - http://www.nature.com/; SCIENTIFIC REPORTS - http://www.nature.com/srep/)

The news correspondents report that additional information may be obtained from N.W. Schmidt, University of Louisville, Dept. of Microbiology and Immunology, Louisville, KY 40202, United States. Additional authors for this research include J.E. Denny, J.B. Powers, H.F. Castro, S.R. Campagna, J.W. Zhang and S. Joshi-Barve.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41598-019-40266-6. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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