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New Autoimmune Hepatitis Findings from Tehran University of Medical Sciences Discussed (Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms In Autoimmune Hepatitis)

Hepatitis Daily News


2019 APR 16 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Daily News -- New research on Autoimmune Diseases and Conditions - Autoimmune Hepatitis is the subject of a report. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, “Introduction and aim. Autoimmune hepatitis (AIH) is an immune-mediated destruction of liver cells, in recognition of interface hepatitis, seropositivity for autoantibodies, and interface hepatitis in histology sections.”

Financial support for this research came from Tehran University of Medical Sciences.

The news reporters obtained a quote from the research from the Tehran University of Medical Sciences, “Hepatocyte destruction in AIH is the direct result of CD4(+) T-cell destruction. Yet, Th17 mediated immune attach and a diversity of cytokine networks, including pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Interleukin 6 (IL-6), set the stage for the destructive liver damage. Peripheral blood samples from 57 patients, with AIH, recruited from referrals to the main pediatric hospital in Tehran. Single nucleotide polymorphisms for the following cytokines genes, were evaluated through, polymerase chain reaction with sequence-specific primers (PCR-SSP) assay: IL-1a (C/T -889), IL-1 alpha (C/T -511), IL-1 beta (C/T + 3962), IL-1 receptor (IL-1R; C/T Pst-I 1970), IL-1RA (C/T Mspa-I 11100), and IL-6 (C/G -174 and A/G nt565). Significant higher frequency of genotype AA was detected in patients in IL-6 at position nt565 (15.8% in AIH patients vs. 2.9% in controls, p = 0.003). The haplotype GA of IL-6 at -174 and nt565, was significantly overrepresented in the AIH group, compared to (20.9% of AIH vs. 1.4% in controls p< 0.0001). Results of our study, indicate significant deviation toward high yield IL-6 polymorphisms, in AIH patients.”

According to the news reporters, the research concluded: “These data could bring new insights in pathophysiology of disease, which could contribute to developing novel treatments for AIH.”

For more information on this research see: Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms In Autoimmune Hepatitis. Annals of Hepatology, 2018;17(6):1021-1025. Annals of Hepatology can be contacted at: Mexican Assoc Hepatology, Punte De Piedra 150, Colonia Toriello Guerra, Mexico, Df Cp 14040, Mexico.

Our news correspondents report that additional information may be obtained by contacting N. Rezaei, Tehran University of Medical Sciences, Children’s Medical Center, Research Center for Immunodeficiencies, Tehran, Iran. Additional authors for this research include A. Yousefi, M. Najafi, F. Motamed, F. Farhmand, A. Khodadad, G. Fallahi, E. Mahmoudi, F. Rahman, A.Z. Bidoki and M. Sadr.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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