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Northwest A&F University Reports Findings in Food Science (Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-kB Signaling Pathways)

Agriculture Daily


2019 MAY 03 (NewsRx) -- By a News Reporter-Staff News Editor at Agriculture Daily -- Investigators discuss new findings in Science - Food Science. According to news reporting originating in Shaanxi, People’s Republic of China, by NewsRx journalists, research stated, “Neuroinflammation has been intensively demonstrated to be related to various neurodegenerative diseases including Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). A natural polymethoxylated flavone, nobiletin (NOB) has been reported to alleviate oxidative stress, insulin resistance, and obesity.”

Funders for this research include Ministry of Science and Technology of the People’s Republic of China, Ministry of Education of the People’s Republic of China, University Association for Science and Technology in Shanxi.

The news reporters obtained a quote from the research from Northwest A&F University, “In this study, we evaluated the protection effects of NOB on neuroinflammation and memory deficit. Three-month mice were administrated with NOB by oral gavage every day for 6 weeks (100 mg/kg/day); subsequently mice were injected intraperitoneally with lipopolysaccharide (LPS) for 7 days. Results of behavioral tests revealed that NOB dramatically ameliorated LPS-triggered memory deficit regarding synaptic dysfunctions and neuronal loss. Also, NOB suppressed the microglial activation and proinflammatory cytokine secretion, such as COX-2, IL-1b, TNF-a, and iNOS. Similarly, upon LPS stimulation, pretreatment NOB diminished the secretion of the proinflammatory cytokines in BV-2 microglia cells by exposure to LPS via modulating MAPKs, PI3K/AKT, and NF-kB signaling pathways. In addition, NOB alleviated LPS-amplified redox imbalance, disturbance of mitochondrial membrane potential (MMP), and dampening of the expression of protein related to mitochondrial respiration.”

According to the news reporters, the research concluded: “The present study provides compelling evidence that NOB decreased LPS-stimulated neuroinflammation and memory impairment through maintaining cellular oxidative balance and blocking the NF-kB transcriptional pathway, illustrating that the nutritional compound NOB may serve as a potential approach to alleviate neuroinflammation-related diseases.”

For more information on this research see: Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-kB Signaling Pathways. Journal of Agricultural and Food Chemistry, 2019;():. (American Chemical Society -; Journal of Agricultural and Food Chemistry -

Our news correspondents report that additional information may be obtained by contacting G. Qi, Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China. Additional authors for this research include Y. Mi, R. Fan, R. Li, Z. Liu and X. Liu.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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