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Data on Alzheimer Disease Reported by Researchers at Department of Epidemiology and Health Statistics (Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer’s Disease)

NewsRx Drug Daily


2019 MAY 06 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Research findings on Neurodegenerative Diseases and Conditions - Alzheimer Disease are discussed in a new report. According to news reporting out of Guangdong, People’s Republic of China, by NewsRx editors, research stated, “To observe the effects of resveratrol (Res) on the antioxidative function and estrogen level in an Alzheimer’s disease (AD) mouse model. First, we examined the effects of Res on an AD mice model.”

Financial support for this research came from 2016 Traditional Chinese Medicine Scientific Research Project of the Guangdong Traditional Chinese Medicine Bureau.

Our news journalists obtained a quote from the research from the Department of Epidemiology and Health Statistics, “SAMP8 mice were selected as the model, and normal-aging SAMR1 mice were used as the control group. The model mice were randomly divided into three groups: a model group, high-dose Res group (40mg/kg, intraperitoneal (ip)), and low-dose Res group (20mg/kg, ip). After receiving medication for 15 days, the mice were subjected to the water maze test to assess their spatial discrimination. The spectrophotometric method was used to detect the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) as well as the malondialdehyde (MDA) content. Quantitative PCR (q-PCR) was used to detect SOD, GSH-Px, CAT, and heme oxygenase-1 (HO-1) mRNA level changes. Western blot analysis detected HO-1 and Nrf2 protein expression. Second, we researched the effect of Res on the estrogen level in the SAMP8 model mice. The model mice were randomly divided into four groups: a model group, estrogen replacement group (0.28 mg/kg, intramuscular (im), estradiol benzoate), high-dose Res group (5 mg/kg, im), and low-dose Res group (2.5 mg/kg, im). The mice were injected, once every three days, for 5 weeks. Q-PCR was used to detect brain tissue mRNA expression changes. Western blot analysis detected ER, ER, and ChAT protein expression. An enzyme-linked immunosorbent assay (ELISA) kit was used to detect the expression of E2 and amyloid protein (A) in brain tissue. Compared with the control treatment, Res could improve the spatial abilities of the mice to a certain extent and also increase the expression of SOD, GSH-Px, CAT, and HO-1 at the mRNA level (p <0.05). In addition, enhanced SOD, GSH-Px, and CAT activities and HO-1 protein levels and decreased MDA content (p <0.05) were detected in the brain tissue of the Res-treated mice. The cytoplasmic Nrf2 content in the Res-treated mice was also decreased while the nuclear Nrf2 content and the nuclear translation rate of Nrf2 were increased (p <0.05). Res could decrease the expression of ER in the brain tissue at the mRNA and protein levels and the expression of A in the brain tissue at the protein level. Res could also increase the mRNA and protein expression of ER and ChAT and the protein expression of estradiol in the brain tissue. Res can increase the antioxidant capacity of AD models through the Nrf2/HO-1 signaling pathway. In addition, Res can enhance estrogen levels in an AD model.”

According to the news editors, the research concluded: “These findings provide a new idea for the treatment of AD.”

For more information on this research see: Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer’s Disease. BioMed Research International, 2019;2019():1-8.

Our news journalists report that additional information may be obtained by contacting D. Kong, Dept. of Epidemiology and Health Statistics, Public Health School of Guangdong Medical University, Dongguan 523808, Guangdong, People’s Republic of China. Additional authors for this research include Y. Yan, X.Y. He, H. Yang, B. Liang, J. Wang, Y. He, Y. Ding and H. Yu.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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