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Reports Outline Geriatrics and Gerontology Study Findings from University of Shandong (Exogenous Testosterone Alleviates Cardiac Fibrosis and Apoptosis Via Gas6/axl Pathway In the Senescent Mice)

Health & Medicine Daily

05-09-19

2019 MAY 08 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- A new study on Aging Research - Geriatrics and Gerontology is now available. According to news reporting from Shandong, People’s Republic of China, by NewsRx journalists, research stated, “Androgen has been implicated in aging-related cardiac remodeling, but its precise role in aging heart remains controversial. We aimed to investigate the role of testosterone in the development of aging-related cardiac remodeling and the mechanisms involved.”

Financial supporters for this research include National Natural Science Foundation of China, Key research and development program of Shandong Province, Natural Science Foundation of Shandong Province.

The news correspondents obtained a quote from the research from the University of Shandong, “Wild type and Axl knockout mice (Axl(-/-)) were randomized into three groups: the young group (n = 30, 3 months old), the aging group (n = 30, 18 months old), the testosterone undecanoate treatment group (TU, n = 30, 18 months old). Mice in the TU group were given testosterone undecanoate (39 mg/kg) by subcutaneous injection on the back at fifteen-months-old, once a month, a total of three times. The old group received solvent reagent (corn oil) by the same method. The aging mice exhibited a decrease in serum testosterone, and Gas6 levels and an increase in apoptosis, and manifested cardiac fibrosis. Testosterone injection to wild type mice increased the levels of testosterone and Gas6 in serum and decreased cardiac apoptosis and fibrosis. Axl(-/-) mice receiving testosterone injection exhibited no obvious improvement in cardiac remodeling although the levels of testosterone and Gas6 in serum elevated. These data indicated that testosterone replacement therapy (TRT) alleviates cardiac fibrosis and apoptosis, at least in part by enhancing Gas6 expression. Moreover, deletion of Axl disables testosterone, which indicated that Axl is an important downstream regulator of testosterone.”

According to the news reporters, the research concluded: “TRT would improve aging-related cardiac remolding via Gas6/Axl signaling pathway, implicating its therapeutic potential to treat aging-related heart disease.”

For more information on this research see: Exogenous Testosterone Alleviates Cardiac Fibrosis and Apoptosis Via Gas6/axl Pathway In the Senescent Mice. Experimental Gerontology, 2019;119():128-137. Experimental Gerontology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Experimental Gerontology - http://www.journals.elsevier.com/experimental-gerontology/)

Our news journalists report that additional information may be obtained by contacting J. Zhao, University of Shandong, Qilu Hospital, Chinese Ministry of Health, Key Lab Cardiovasc Remodeling & Funct Res, Chinese, 107 Wen Hua Xi Rd, Jinan 250012, Shandong, People’s Republic of China. Additional authors for this research include F.F. Chen, F.Q. Song, Y.Q. Chen, Z.H. Wang, Y.H. Li, M.H. Liu, Y. Li, M. Song, W. Zhang and M. Zhong.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.exger.2019.01.029. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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