Studies from Mediterranean Institute for Life Sciences Yield New Information about Dermatology (Ecobiological approach to research regarding ageing and diseases)
Health & Medicine Daily
2019 MAY 08 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Investigators publish new report on Health and Medicine - Dermatology. According to news reporting originating from Aix en Provence, France, by NewsRx editors, the research stated, “Ageing and age-related diseases (ARD) share a common biological clock that appears as their root cause: protein damage. A majority of proteins have evolved into native structures resistant to oxidative damage but any folding imperfections, including those due to ‘silent’ amino acid substitutions, reduce oxidation resistance.”
Our news editors obtained a quote from the research from Mediterranean Institute for Life Sciences, “Damaged proteins accumulate with age and trigger ageing-like phenotypes reversible by their turnover, while acquired genome alterations remain as stable consequences of protein malfunction. Ageing and ARD display species-specific latency in phenotypic expression. Disease latency may be proposed as to be due to phenotypic suppression of cellular defects by molecular traffic among neighbouring cells. Such cross-complementation of functional deficiencies acts as a kind of tissue-based cellular ‘solidarity’, called cellular parabiosis. Chronic inflammation reveals dormant cell phenotypes and shortens disease latency by the breakdown of cell-cell communication, as in tumor promotion and inflammation.”
According to the news editors, the research concluded: “At the present time, predictive diagnostics, prognostics, prevention and even cure of disease by phenotypic reversion become conceivable.”
For more information on this research see: Ecobiological approach to research regarding ageing and diseases. European Journal of Dermatology, 2019;29(S1):11-14.
The news editors report that additional information may be obtained by contacting M. Radman, Mediterranean Institute for Life Sciences, Split, Croatia, Naos Institute for Life Sciences, Aix-en-Provence, France, Universite R-Descartes Paris-5, faculte de medecine, INSERM U1001, Paris, France.
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