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Investigators at Center for Reproductive Medicine Detail Findings in Erectile Dysfunction (Association Between Serum High-sensitivity C-reactive Protein Levels and Erectile Dysfunction: a Cross-sectional Study of Chinese Male Population)

Proteomics Daily

05-10-19

2019 MAY 09 (NewsRx) -- By a News Reporter-Staff News Editor at Proteomics Daily -- Researchers detail new data in Genital Diseases and Conditions - Erectile Dysfunction. According to news reporting from Shandong, People’s Republic of China, by NewsRx journalists, research stated, “Inflammation has been known to affect endothelial function and is involved in the progression of erectile dysfunction (ED). Thus, our present study was conducted to investigate the association between inflammatory marker high-sensitivity C-reactive protein (hs-CRP) and ED in a Chinese male population.”

Financial support for this research came from Science Foundation of The People’s Hospital of LaiWu City.

The news correspondents obtained a quote from the research from Center for Reproductive Medicine, “A total of 1515 participants with anthropometric measurements, serum analyses and hs-CRP values available were included in our cross-sectional study. Data involving socioeconomic and lifestyle factors were also collected. ED was assessed by the 5-item International Index Erectile Function (IIEF-5), and hs-CRP levels were measured by the immunoturbidimetric assay. Logistic regression was applied to estimate the association between the serum hs-CRP and the risk of ED, and receiver operating characteristics (ROC) curve analysis was performed to identify the predictive value of hs-CRP. Serum hs-CRP levels were significantly higher in ED patients, and increased progressively with the incremental severity of ED (P < 0.001 for trend). In the multivariate-adjusted model, men in the highest quartile of hs-CRP level versus those in the lowest quartile had a 50% increased likelihood for ED (OR = 1.50; 95% CI = 1.08-2.08). When subjects were stratified by age, the risk of ED was more prominently in the middle-aged and elderly men. Based on the ROC analysis, serum hs-CRP has a poor diagnostic value for ED with an AUC of 0.58 (95% CI: 0.56-0.61) but has a good diagnostic performance for differentiating severe ED (AUC: 0.79; 95% CI: 0.77-0.81). Our study indicates that increased serum hs-CRP levels are associated with the severity of ED and an increased ED risk in a Chinese male population.”

According to the news reporters, the research concluded: “These findings suggest that hs-CRP may be of value as an inflammatory marker for the assessment of ED risk and may play an important role in the etiology of ED.”

For more information on this research see: Association Between Serum High-sensitivity C-reactive Protein Levels and Erectile Dysfunction: a Cross-sectional Study of Chinese Male Population. SCIENTIFIC REPORTS, 2019;9():. SCIENTIFIC REPORTS can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - http://www.nature.com/; SCIENTIFIC REPORTS - http://www.nature.com/srep/)

Our news journalists report that additional information may be obtained by contacting X.H. Wang, Taishan Medical College, LaiWu Affiliated Hosp, Peoples Hosp LaiWu City, Center for Reproductive Medicine, Dept. of Obstetrics and Gynecology, Tai An, Shandong, People’s Republic of China. Additional authors for this research include W.Y. Li, K. Chen, Y.H. Zhu, Y. Lv, J.P. Zhang and G.Y. Xu.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41598-019-42342-3. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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