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Recent Findings from Sree Chitra Tirunal Institute For Medical Sciences and Technology Has Provided New Information about Alzheimer Disease (Apolipoprotein E Polymorphism and Oxidative Stress In Peripheral Blood-derived Macrophage-mediated ...)

Daily India Report

05-13-19

2019 MAY 10 (NewsRx) -- By a News Reporter-Staff News Editor at Daily India Report -- New research on Neurodegenerative Diseases and Conditions - Alzheimer Disease is the subject of a report. According to news originating from Thiruvananthapuram, India, by NewsRx correspondents, research stated, “Peripheral blood-derived macrophages isolated from Alzheimer’s disease (AD) patients have earlier been reported to demonstrate ineffective phagocytosis of amyloid-beta compared to the age-matched control subjects. However, the mechanisms causing unsuccessful phagocytosis remain unclear.”

Funders for this research include Indian Council of Medical Research, Government of India, research fellowship Council of Scientific and Industrial Research, Institute research fellowship from SCTIMST.

Our news journalists obtained a quote from the research from Sree Chitra Tirunal Institute For Medical Sciences and Technology, “Oxidative stress and the presence of ApoE epsilon 4 allele has been reported to play a major role in the pathogenesis of AD, but the contribution of oxidative stress and ApoE epsilon 4 in macrophage dysfunction leading to ineffective A phagocytosis needs to be analyzed. A phagocytosis assay has been performed using FITC-labeled A and analyzed using flow cytometry and confocal imaging in patient samples and in THP-1 cells. Oxidative stress in patient-derived macrophages was analyzed by assessing the DNA damage using comet assay. ApoE polymorphism was analyzed using sequence-specific PCR and Hixson & Vernier Restriction isotyping protocol. In this study, we have analyzed the patterns of phagocytic inefficiency of macrophages in Indian population with a gradual decline in the phagocytic potential from mild cognitive impairment (MCI) to AD patients. Further, we have shown that the presence of ApoE epsilon 4 allele might also have a possible effect on the phagocytosis efficiency of the macrophages. Here, we demonstrate for the first time that oxidative stress could affect the amyloid-beta phagocytic potential of macrophages and hence by alleviating oxidative stress using curcumin, an anti-oxidant could enhance the amyloid-beta phagocytic efficacy of macrophages of patients with AD and MCI, although the responsiveness to curcumin might depends on the presence or absence of APOE epsilon 4 allele. Oxidative stress contributes significantly to decreased phagocytosis of A by macrophages. Moreover, the phagocytic inefficiency of macrophages was correlated to the presence of ApoE epsilon 4 allele.”

According to the news editors, the research concluded: “This study also found that the A-phagocytic potential of macrophage gets significantly enhanced in curcumin-treated patient-derived macrophages.”

For more information on this research see: Apolipoprotein E Polymorphism and Oxidative Stress In Peripheral Blood-derived Macrophage-mediated Amyloid-beta Phagocytosis In Alzheimer’s Disease Patients. Cellular and Molecular Neurobiology, 2019;39(3):355-369. Cellular and Molecular Neurobiology can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Cellular and Molecular Neurobiology - http://www.springerlink.com/content/0272-4340/)

The news correspondents report that additional information may be obtained from S. Gopala, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Dept. of Biochemistry, Thiruvananthapuram 695011, Kerala, India. Additional authors for this research include P.S. Jairani, P.M. Aswathy, R.N. Menon, P.S. Mathuranath, D. Krishnan and J. Verghese.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10571-019-00651-1. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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