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New Atherosclerosis Data Have Been Reported by Researchers at Johns Hopkins University (Systemic Inflammation During Midlife and Cognitive Change Over 20 Years)

Disease Prevention Daily

05-15-19

2019 MAY 14 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Research findings on Cardiovascular Diseases and Conditions - Atherosclerosis are discussed in a new report. According to news originating from Baltimore, Maryland, by NewsRx correspondents, research stated, “To examine the association between systemic inflammation measured during midlife and 20-year cognitive decline. Within the Atherosclerosis Risk in Communities cohort study, inflammatory biomarkers were measured during middle adulthood.”

Funders for this research include National Heart, Lung, and Blood Institute, NHLBI, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases.

Our news journalists obtained a quote from the research from Johns Hopkins University, “We created an inflammation composite score using 4 blood biomarkers measured at visit 1 (fibrinogen, white blood cell count, von Willebrand factor, and factor VIII); we measured C-reactive protein (CRP) at visit 2. Cognition was assessed over 3 visits spanning 20 years using measures of memory, executive function, and language. A total of 12,336 participants (baseline age 56.8 [5.7], 21% black, 56% women) were included. After adjusting for demographic variables, vascular risk factors, and comorbidities, each standard deviation (SD) increase in midlife inflammation composite score was associated with an additional 20-year decline of -0.035 SD (95% confidence interval: -0.062 to -0.007) on the cognitive composite score. We found a similar association between each SD increase in midlife CRP level and additional 20-year cognitive decline (-0.038 SD, 95% confidence interval: -0.057 to -0.019). Participants with a midlife inflammation composite score in the top quartile had a 7.8% steeper cognitive decline, compared to participants in the lowest quartile; CRP in the top quartile was associated with an 11.6% steeper cognitive decline. In cognitive domain-specific analyses, elevated midlife inflammatory markers were most consistently associated with declines in memory. Results were similar after adjusting for attrition using inverse probability weighting.”

According to the news editors, the research concluded: “Our findings highlight what may be an early pathogenic role for systemic inflammation as a driver of cognitive decline in the decades leading up to older adulthood.”

For more information on this research see: Systemic Inflammation During Midlife and Cognitive Change Over 20 Years. Neurology, 2019;92(11):E1256-E1267. Neurology can be contacted at: Lippincott Williams & Wilkins, Two Commerce Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Lippincott Williams and Wilkins - www.lww.com; Neurology - neurology.org)

The news correspondents report that additional information may be obtained from K.A. Walker, Johns Hopkins University, Dept. of Neurology, Baltimore, MD 21218, United States. Additional authors for this research include R.F. Gottesman, A.Z. Wu, A.L. Gross, E. Selvin, D.S. Knopman, T.H. Mosley and B.G. Windham.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1212/WNL.0000000000007094. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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