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New Findings from Department of Food and Nutrition Describe Advances in Armadillo Domain Proteins (Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis Via Wnt/beta-catenin/atf4 Signaling Pathways)

Biotech News Daily


2019 MAY 14 (NewsRx) -- By a News Reporter-Staff News Editor at Biotech News Daily -- Current study results on Proteins - Armadillo Domain Proteins have been published. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, “This study evaluated the effects of vitamin C on osteogenic differentiation and osteoclast formation, and the effects of vitamin C concentration on bone microstructure in ovariectomized (OVX) Wistar rats. Micro-computed tomography analysis revealed the recovery of bone mineral density and bone separation in OVX rats treated with vitamin C. Histomorphometrical analysis revealed improvements in the number of osteoblasts, osteoclasts, and osteocytes; the osteoblast and osteoclast surface per bone surface; and bone volume in vitamin C-treated OVX rats.”

Financial support for this research came from Kwang-Dong Pharmaceutical Co. Ltd..

The news reporters obtained a quote from the research from the Department of Food and Nutrition, “The vitamin C-treated group additionally displayed an increase in the expression of osteoblast differentiation genes, including bone morphogenetic protein-2, small mothers against decapentaplegic 1/5/8, runt-related transcription factor 2, osteocalcin, and type I collagen. Vitamin C reduced the expression of osteoclast differentiation genes, such as receptor activator of nuclear factor kappa-B, receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase, and cathepsin K. This study is the first to show that vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of wingless-type MMTV integration site family/beta-catenin/activating transcription factor 4 signaling, which is achieved through the serine/threonine kinase and mitogen-activated protein kinase signaling pathways.”

According to the news reporters, the research concluded: “Therefore, our results suggest that vitamin C improves bone regeneration.”

For more information on this research see: Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis Via Wnt/beta-catenin/atf4 Signaling Pathways. NUTRIENTS, 2019;11(3):. NUTRIENTS can be contacted at: Mdpi, St Alban-Anlage 66, Ch-4052 Basel, Switzerland.

Our news correspondents report that additional information may be obtained by contacting J.H. An, Kc Univ, Dept. of Food and Nutrition, Seoul 077661, South Korea. Additional authors for this research include H.K. Choi, G.J. Kim, H.S. Yoo, D.H. Song, K.H. Chung, K.J. Lee and Y.T. Koo.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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