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New Tauopathies Findings from Temple University Discussed (Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy)

Pain & Central Nervous System Daily News

05-17-19

2019 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Research findings on Neurodegenerative Diseases and Conditions - Tauopathies are discussed in a new report. According to news reporting originating in Philadelphia, United States, by NewsRx journalists, research stated, “A high circulating level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer’s disease (AD). Previous studies show that elevated Hcy promotes brain amyloidosis and behavioral deficits in mouse models of AD.”

The news reporters obtained a quote from the research from Temple University, “However, whether it directly modulates the development of tau neuropathology independently of amyloid beta in vivo is unknown. Herein, we investigate the effect of diet-induced elevated levels of brain Hcy on the phenotype of a relevant mouse model of human tauopathy. Compared with controls, tau mice fed with low folate and B vitamins diet had a significant increase in brain Hcy levels and worsening of behavioral deficits. The same mice had a significant elevation of tau phosphorylation, synaptic pathology, and astrocytes activation. In vitro studies demonstrated that Hcy effect on tau phosphorylation was mediated by an upregulation of 5-lipoxygenase via cdk5 kinase pathway activation.”

According to the news reporters, the research concluded: “Our findings support the novel concept that high Hcy level in the central nervous system is?a metabolic risk factor for neurodegenerative diseases, specifically characterized by the progressive accumulation of tau pathology, namely tauopathies.”

For more information on this research see: Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy. Molecular Psychiatry, 2018;():. (Nature Publishing Group - http://www.nature.com/; Molecular Psychiatry - http://www.nature.com/mp/)

Our news correspondents report that additional information may be obtained by contacting D. Pratico, Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, United States. Additional authors for this research include J.G. Li, C. Barrero, S. Merali and D. Pratico.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1038/s41380-018-0062-0. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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