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Findings from University of Fudan in the Area of Type 2 Diabetes Reported

Disease Prevention Daily

05-17-19

2019 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Current study results on Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes have been published. According to news originating from Shanghai, People’s Republic of China, by NewsRx correspondents, research stated, “This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) of Forkhead box O3 (FOXO3) gene with type 2 diabetes mellitus (T2D). A total of 843 elderly residents from east China were enrolled in this study, which included 426 patients with type 2 diabetes and 417 controls.”

Funders for this research include National Natural Science Foundation of China, Shanghai Sailing Program.

Our news journalists obtained a quote from the research from the University of Fudan, “Four SNPs were analyzed by qPCR. Genotype frequencies of the 4 SNPs in FOXO3 of the patients and controls were analyzed using logistic regression analysis. The association between each SNP and clinical indicators was analyzed by linear regression analysis. None of the 4 FOXO3 variants, rs13217795, rs2764264, rs2802292, and rs13220810, were associated with the risk of type 2 diabetes compared to controls. However, rs13217795, rs2764264, and rs2802292 were associated with lower blood glucose levels. Notably, further subgroup analysis indicated that the longevity-associated alleles of FOXO3 SNP (rs13217795, rs2764264, and rs2802292) were associated with lower blood glucose levels in women (TC versus TT, -0.724 mmol/L, P=0.005; CC versus TT, -1.093 mmol/L, P=0.03; TC versus TT, -0.801 mmol/L, P=0.002; CC versus TT, -1.212 mmol/L, P=0.001; TG versus TT, -0.754 mmol/L, P=0.004; and GG versus TT, -1.150 mmol/L, P=0.001) but not in men.”

According to the news editors, the research concluded: “The results indicated that longevity-associated FOXO3 variants were correlated with lower blood glucose levels in elderly women with type 2 diabetes in east China.”

For more information on this research see: Longevity-associated Forkhead Box O3 (Foxo3) Single Nucleotide Polymorphisms Are Associated With Type 2 Diabetes Mellitus In Chinese Elderly Women. MEDICAL SCIENCE MONITOR, 2019;25():2966-2975. MEDICAL SCIENCE MONITOR can be contacted at: Int Scientific Information, Inc, 150 Broadhollow Rd, Ste 114, Melville, NY 11747, USA.

The news correspondents report that additional information may be obtained from L.S. Wang, University of Fudan, Inst Fudan Minhang Acad Hlth Syst, Minhang Hospital, Shanghai, People’s Republic of China. Additional authors for this research include Y.Q. Mao, J.F. Liu and B. Han.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.12659/MSM.913788. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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