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New Colon Cancer Findings from Nagoya City University Outlined (Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL-6 and VEGF from colon cancer-associated fibroblasts)

Angiogenesis Daily

05-17-19

2019 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Angiogenesis Daily -- Research findings on Oncology - Colon Cancer are discussed in a new report. According to news reporting from Nagoya, Japan, by NewsRx journalists, research stated, “Eicosapentaenoic acid (EPA) improves interleukin (IL)-6 hypercytokinemia in patients with advanced cancer due to its anti-inflammatory effects. This EPA mechanism has been revealed to lead to several anticancer effects.”

The news correspondents obtained a quote from the research from Nagoya City University, “While the effects of EPA on cancer cells have been investigated, particularly in terms of angiogenesis, its effects on the tumor stroma remain unclear. In the present study, the authors clarified the role of EPA in cancer angiogenesis against colon cancer-associated fibroblasts (CAFs) from the colon stroma. With established human CAFs and normal fibroblasts from colon stroma (NFs), the authors evaluated IL-6 and vascular endothelial growth factor (VEGF) secretion with or without EPA treatment using ELISA. The signal inhibition of mitogen-activated protein kinase (ERK) in CAFs by EPA was evaluated using western blotting. In vitro anti-angiogenesis effects were evaluated by the angiogenesis assay on Matrigel using human umbilical vein endothelial cells (HUVECs) cultured with the supernatant obtained from CAF cultures with or without EPA. IL-6 secretion was greater from CAFs compared with that from NFs and stimulation with lipopolysaccharide (LPS) resulted in greater IL-6 secretion from the two fibroblast types compared with that from fibroblasts without LPS stimulation. While LPS stimulation increased VEGF secretion from the two fibroblast types, EPA decreased IL-6 and VEGF secretion from CAFs. Western blotting revealed that the addition of 30 ?M EPA inhibited the ERK phosphorylation signal in CAFs. Furthermore, the angiogenesis assay with Matrigel revealed that the CAF culture supernatants treated with EPA suppressed tubular formation in HUVECs. These reductions may have been caused by the inhibition of ERK phosphorylation by EPA. Thus, EPA reduces cancer angiogenesis associated with CAFs.”

According to the news reporters, the research concluded: “Additional studies will be needed to clarify the continuous anti-angiogenetic effect of chemotherapy using angiogenesis inhibitors (e.g. bevacizumab and aflibercept) in conjunction with or without EPA, and the clinical usage of EPA in conjunction with chemotherapy in vivo.”

For more information on this research see: Eicosapentaenoic acid suppresses angiogenesis via reducing secretion of IL-6 and VEGF from colon cancer-associated fibroblasts. Oncology Reports, 2019;():.

Our news journalists report that additional information may be obtained by contacting N. Ando, Dept. of Gastroenterological Surgery, Nagoya City University, Mizuho-ku, Nagoya 467-8601, Japan. Additional authors for this research include M. Hara, K. Shiga, T. Yanagita, K. Takasu, N. Nakai, Y. Maeda, T. Hirokawa, H. Takahashi, H. Ishiguro, Y. Matsuo and S. Takiguchi.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.3892/or.2019.7141. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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