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New Alzheimer Disease Findings Reported from Tabriz University of Medical Sciences (Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/progenitor Cell Proliferation and Neurogenesis In the Adult Rat Dentate Gyrus)

Middle East Daily

05-21-19

2019 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Middle East Daily -- Researchers detail new data in Neurodegenerative Diseases and Conditions - Alzheimer Disease. According to news reporting originating in Tabriz, Iran, by NewsRx journalists, research stated, “The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin.”

Financial support for this research came from Tabriz University of Medical Sciences.

The news reporters obtained a quote from the research from the Tabriz University of Medical Sciences, “Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer’s disease induced by amyloid-beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid-beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid-beta injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one-month quercetin treatment alleviated the detrimental effects of amyloid-beta on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis.”

According to the news reporters, the research concluded: “These data suggest that quercetin can play a valuable role in alleviating Alzheimer’s disease symptoms by enhancing adult neurogenesis mechanism.”

For more information on this research see: Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/progenitor Cell Proliferation and Neurogenesis In the Adult Rat Dentate Gyrus. International Journal of Developmental Neuroscience, 2019;74():18-26. International Journal of Developmental Neuroscience can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; International Journal of Developmental Neuroscience - http://www.journals.elsevier.com/international-journal-of-developmental-neuroscience/)

Our news correspondents report that additional information may be obtained by contacting M. Karimipour, Tabriz University of Medical Sciences, Faculty of Medicine, Dept. of Anatomical Sciences, Tabriz, Iran. Additional authors for this research include H. Tayefi, R. Rahbarghazi, H.S. Bagheri, J. Mahmoudi, M. Shimia and M. Ghanadian.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.ijdevneu.2019.02.005. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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