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New Biomarkers Study Findings Reported from German Cancer Research Center (Oxidative Stress and Epigenetic Mortality Risk Score: Associations With All-cause Mortality Among Elderly People)

Health & Medicine Daily

05-21-19

2019 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New research on Diagnostics and Screening - Biomarkers is the subject of a report. According to news reporting out of Heidelberg, Germany, by NewsRx editors, research stated, “Oxidative stress (OS) has been found to be related to accelerated aging and many aging-related health outcomes. Recently, an epigenetic mortality risk score (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be associated with all-cause mortality.”

Financial supporters for this research include Baden-Wurttemberg state Ministry of Science, Research and Arts (Stuttgart, Germany), Federal Ministry of Education and Research (Berlin, Germany), Federal Ministry of Family Affairs, Senior Citizens, Women and Youth (Berlin, Germany), German Research Foundation (DFG), China Scholarship Council (CSC).

Our news journalists obtained a quote from the research from German Cancer Research Center, “This study aimed to address the association between OS and MS, and to assess and compare their performance in the prediction of all-cause mortality. For 1448 participants aged 50-75 of the German ESTHER cohort study, the MS was derived from the DNA methylation profiles measured by Illumina HumanMethylation450K Beadchip and the levels of two urinary OS markers, 8-isoprostane (8-iso) and oxidized guanine/guanosine [including 8-hydroxy-2-deoxyguanosine (8-oxo)], were measured by ELISA kits. Associations between OS markers and the MS were evaluated by linear and ordinal logisticregression models, and their associations with all-cause mortality were examined by Cox regression models. Both OS markers were associated with the MS at baseline. The 8-iso levels and MS, but not 8-oxo levels, were associated with all-cause mortality during a median follow-up of 15.1years. Fully-adjusted hazard ratios (95% CI) were 1.56 (1.13-2.16) for the 4th quartile of 8-iso levels compared with the 1st, 1.71 (1.27-2.29) and 2.92 (2.03-4.18) for the moderate and high MS defined by 2-5 and >5 CpG sites with aberrant methylation compared with a MS of 0-1, respectively. After controlling for 8-iso levels, the hazard ratios of MS remained essentially unchanged while the association of 8-iso levels with mortality was attenuated.”

According to the news editors, the research concluded: “This study demonstrates that OS is highly associated with the epigenetic MS, and the latter at the same time has a higher predictive value for all-cause mortality.”

For more information on this research see: Oxidative Stress and Epigenetic Mortality Risk Score: Associations With All-cause Mortality Among Elderly People. European Journal of Epidemiology, 2019;34(5):451-462. European Journal of Epidemiology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; European Journal of Epidemiology - http://www.springerlink.com/content/0393-2990/)

Our news journalists report that additional information may be obtained by contacting H. Brenner, German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Neuenheimer Feld 581, D-69120 Heidelberg, Germany. Additional authors for this research include X. Gao, Y. Zhang, B. Schottker and B. Holleczek.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10654-019-00493-7. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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