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New Findings from University of Mysore in the Area of Biogerontology Reported (Oxidative stress resistance as a factor in aging: evidence from an extended longevity phenotype of Drosophila melanogaster)

Daily India Report

05-21-19

2019 MAY 20 (NewsRx) -- By a News Reporter-Staff News Editor at Daily India Report -- Researchers detail new data in Aging Research - Biogerontology. According to news reporting from Mysuru, India, by NewsRx journalists, research stated, “Longevity of a species is a multifactorial quantitative trait influenced by genetic background, sex, age and environment of the organism. Extended longevity phenotypes (ELP) from experimental evolution in the laboratory can be used as model systems to investigate the mechanisms underlying aging and senescence.”

The news correspondents obtained a quote from the research from the University of Mysore, “ELPs of Drosophila are correlated with various life history attributes such as resistance to environmental stressors (starvation, desiccation, cold and paraquat), developmental time, biochemical defenses, etc. The association between oxidative stress resistance and longevity is not clear and ELPs offer an opportunity to examine the role of oxidative stress resistance in longevity. Here, we have investigated the hypothesis that enhanced oxidative stress resistance and elevated antioxidant defense system play a positive role in longevity using an ELP of Drosophila melanogaster. An ELP of D. melanogaster isolated and characterized in our laboratory through artificial selection (inbred laboratory strain of Oregon K) is employed in this study. Our ELP, named as long lifespan (LLS) flies, shows marked extension in lifespan when compared to the progenitor population (normal lifespan, NLS) and makes a suitable model to study the role of mitochondrial genome in longevity because of its least heterogeneity. In this study, sensitivity to ethanol with age was employed as a measure of resistance to oxidative stress in NLS and LLS flies. Effect of age and oxidative stress on longevity was examined by employing NLS and LLS flies of different age groups against ethanol-induced oxidative stress. Results show that the lower mortality against ethanol was associated with enhanced oxidative stress resistance, higher antioxidant defenses, lower reactive oxygen species (ROS) levels, enhanced alcohol dehydrogenase activity and better locomotor ability attributes of LLS flies. In addition, age-related changes like locomotor impairments, decreased antioxidant defenses, higher ROS levels and sensitivity to oxidative stress were delayed in LLS flies when compared to NLS.”

According to the news reporters, the research concluded: “Our study supports the hypothesis that higher oxidative stress resistance and enhanced antioxidant defenses are significant factors in extending longevity.”

For more information on this research see: Oxidative stress resistance as a factor in aging: evidence from an extended longevity phenotype of Drosophila melanogaster. Biogerontology, 2019;():. Biogerontology can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Biogerontology - http://www.springerlink.com/content/1389-5729/)

Our news journalists report that additional information may be obtained by contacting S.R. Ramesh, Dept. of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru, 570006, India, . Additional authors for this research include S. Niveditha, T. Shivanandappa and S.R Ramesh.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10522-019-09812-7. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Biogerontology is: Springer, 233 Spring Street, New York, NY 10013, USA.

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