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Study Findings from Midwestern University Broaden Understanding of Alzheimer Disease (Beneficial Effects of Resveratrol and Exercise Training On Cardiac and Aortic Function and Structure In the 3xtg Mouse Model of Alzheimer’s Disease)

Genomics & Genetics Daily

05-22-19

2019 MAY 21 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Research findings on Neurodegenerative Diseases and Conditions - Alzheimer Disease are discussed in a new report. According to news originating from Glendale, United States, by NewsRx correspondents, research stated, “Studies have indicated an association between Alzheimer’s disease (AD) and increased risk of developing cardiovascular complications. Lifestyle modifiable factors, such as exercise and diet, are known to prevent cardio-cerebral disease.”

Funders for this research include Diabetes Action and Research Education Foundation, Midwestern University Office of Research and Sponsored Programs.

Our news journalists obtained a quote from the research from Midwestern University, “Recent studies demonstrate that hearts from early onset triple-transgenic AD mice exhibit pathologies, but it is not clear whether cardiovascular function is altered in this model. In this study, we measured in vivo cardiovascular function in 7-month-old male 3xTg mice and age-matched wild-type (WT) mice using high-frequency high-resolution ultrasound imaging. Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3xTg and wild-type mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3xTg mice. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3xTg mice compared to WT mice. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Pulse wave velocity was similar to 33% higher in 3xTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Aortic wall and adventitia thickness were increased in 3xTg mice compared to the WT group. Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity. Taken together, the results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3xTg mouse model of AD can be prevented with exercise training and treatment with resveratrol.”

According to the news editors, the research concluded: “The benefits of regular exercise training and resveratrol supplementation of heart and aortic structure in the 3xTg mouse support the value of healthy lifestyle factors on cardiovascular health.”

For more information on this research see: Beneficial Effects of Resveratrol and Exercise Training On Cardiac and Aortic Function and Structure In the 3xtg Mouse Model of Alzheimer’s Disease. DRUG DESIGN DEVELOPMENT AND THERAPY, 2019;13():1197-1211. DRUG DESIGN DEVELOPMENT AND THERAPY can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand.

The news correspondents report that additional information may be obtained from T.L. Broderick, Midwestern University, Lab Diabet & Exercise Metab, Dept. of Physiology, College of Graduate Studies, Glendale, AZ 85308, United States. Additional authors for this research include M. Esfandiarei, B. Hoxha, N.A. Talley, D.M. Eckman, M.R. Anderson, M.F. Alkhouli, M.A. Squire, J.R. Babu and G.D. Lopaschuk.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.2147/DDDT.S196119. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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