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Researchers at University of Ulsan College of Medicine Report Findings in Osteoarthritis (Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture)

Blood Daily News


2019 MAY 21 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Daily News -- Investigators discuss new findings in Musculoskeletal Diseases and Conditions - Osteoarthritis. According to news reporting from Seoul, South Korea, by NewsRx journalists, research stated, “The plasma n-3 fatty acid level was 26.2% lower in patients with osteoporotic hip fracture than in those with osteoarthritis. In all patients, n-3 fatty acid was positively associated with bone mineral density and inversely associated with tartrate-resistant acid phosphatase-5b level in bone marrow aspirates, reflecting the bone microenvironment.”

Financial support for this research came from Ministry of Science ICT and Future Planning.

The news correspondents obtained a quote from the research from the University of Ulsan College of Medicine, “Despite the potential beneficial role of n-3 fatty acid (FA) on bone metabolism, the specific mechanisms underlying these effects in humans remain unclear. Here, we assessed whether the plasma n-3 level, as an objective indicator of its status, is associated with osteoporosis-related phenotypes and bone-related markers in human bone marrow (BM) samples. This was a case-control and cross-sectional study conducted in a clinical unit. n-3 FA in the blood and bone biochemical markers in the BM aspirates were measured by gas chromatography/mass spectrometry and immunoassay, respectively. BM fluids were collected from 72 patients who underwent hip surgery because of either osteoporotic hip fracture (HF; n=28) or osteoarthritis (n=44). After adjusting for confounders, patients with HF had 26.2% lower plasma n-3 levels than those with osteoarthritis (p=0.006), and each standard deviation increment in plasma n-3 was associated with a multivariate-adjusted odds ratio of 0.40 for osteoporotic HF (p=0.010). In multivariate analyses including all patients, a higher plasma n-3 level was associated with higher bone mass at the lumbar spine (b=0.615, p=0.002) and total femur (b=0.244, p=0.045). Interestingly, the plasma n-3 level was inversely associated with the tartrate-resistant acid phosphatase-5b level (b=-0.633, p=0.023), but not with the bone-specific alkaline phosphatase level, in BM aspirates.”

According to the news reporters, the research concluded: “These findings provide clinical evidence that n-3 FA is a potential inhibitor of osteoclastogenesis that favors human bone health.”

For more information on this research see: Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture. Osteoporosis International, 2019;30(5):1071-1078. (Springer -; Osteoporosis International -

Our news journalists report that additional information may be obtained by contacting B.J. Kim, Division of Endocrinology and Metabolism, ASAN Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea, . Additional authors for this research include H.J. Yoo, S.J. Park, M.K. Kwak, S.H. Lee, S.J. Kim, M.W. Hamrick, C.M. Isales, S.H. Ahn and J.M Koh.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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