Eli Lilly's erectile dysfunction drug Cialis shows signs of reversing heart failure in sheep
Syrian Arab News Agency
Eli Lillys Cialis (tadalafil) is best known as an erectile dysfunction (ED) therapy. But
Cialis slowed the progression of heart failure in sheep models of the disease and reversed breathlessness, one of the most troublesome symptoms, the researchers reported in the journal Scientific Reports.
The findings may not be a total surprise. This class of drugs, PDE5 inhibitors, which also includes Pfizers Viagra and Bayers Levitra, was originally developed for cardiac disease. Then the scientists developing Viagra discovered the drug relieved ED.
We do have limited evidence from human trials and epidemiological studies that show Tadalafil can be effective in treating heart failure, said the studys lead author,
Heart failure is characterized by the hearts inability to pump enough blood to meet the bodys needs, which can lead to fluid accumulation in the lungs and cause the feeling of being short of breath. Traffords team used sheep to study the effects of PDE5 inhibition because their hearts are similar to human hearts.
After inducing heart failure in the animals, the team administered Cialis at a dose similar to whats used to treat ED in people. They observed that Cialis restored the hearts ability to respond to adrenalineand that improved its ability to pump blood.
Most heart failure medications can slow the progression of the disease and lower the probability of deadly cardiac events. But actually reversing heart failure is difficult, especially without surgery or the assistance of medical devices.
Various groups of scientists are exploring methods for reversing heart failure with drugs. A team at
We seem to have gone full-circle, with findings from recent studies suggesting that [ED drugs] may be effective in the treatment of some forms of heart diseasein this case, heart failure, said Metin Avkiran, associate medical director of the