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Researchers at Kyushu University Target Alzheimer Disease (Association Between Serum b-alanine and Risk of Dementia: the Hisayama Study)

Mental Health News Daily

06-12-19

2019 JUN 11 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health News Daily -- New research on Neurodegenerative Diseases and Conditions - Alzheimer Disease is the subject of a report. According to news reporting out of Fukuoka, Japan, by NewsRx editors, research stated, “The aim of this study was to examine the association between serum concentrations of b-alanine, a metabolite from carnosine and anserine, and the risk of dementia in a general elderly population of Japanese. In 2007, 1,475 residents of Hisayama, Japan aged 60-79 years without dementia were divided into four groups according to the quartiles of serum b-alanine concentrations (Q1, lowest; Q4, highest) and followed up for 5.3 years (median).”

Our news journalists obtained a quote from the research from Kyushu University, “During the follow-up, 117 subjects developed all-cause dementia (Alzheimer’s in 77 cases and vascular dementia in 31). The risk of all-cause dementia decreased with elevating serum b-alanine levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval]: Q1, 1.00 [reference]; Q2, 0.73 [0.45, 1.18]; Q3, 0.50 [0.28, 0.89]; Q4, 0.50 [0.27, 0.92]; p=0.01 for trend). A similar inverse association was observed for Alzheimer’s disease (Q1, 1.00 [reference]; Q2, 0.78 [0.44, 1.38]; Q3, 0.53 [0.26, 1.06]; Q4, 0.53 [0.25, 1.10]; p=0.04 for trend), but not for vascular dementia.”

According to the news editors, the research concluded: “Higher serum b-alanine levels were significantly associated with lower risks of all-cause dementia and Alzheimer’s disease. Since serum b-alanine levels reflect the intakes of carnosine/anserine, higher intakes of carnosine/anserine may be beneficial for the prevention of dementia.”

For more information on this research see: Association Between Serum b-alanine and Risk of Dementia: the Hisayama Study. American Journal of Epidemiology, 2019;():. (Oxford University Press - http://www.oup.com/; American Journal of Epidemiology - aje.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting J. Hata, Dept. of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Additional authors for this research include T. Ohara, Y. Katakura, K. Shimizu, S. Yamashita, D. Yoshida, T. Honda, Y. Hirakawa, M. Shibata, S. Sakata, T. Kitazono, S. Kuhara and T. Ninomiya.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1093/aje/kwz116. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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