Researchers from National University of La Plata Detail New Studies and Findings in the Area of Stem Cell Research (Rejuvenation By Cell Reprogramming: a New Horizon In Gerontology)
Stem Cell Daily
2019 JUN 18 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Daily -- Current study results on Stem Cell Research have been published. According to news reporting originating from La Plata, Argentina, by NewsRx correspondents, research stated, “The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that aging is a reversible epigenetic process. Here, we will first summarize the experimental achievements over the last 7years in cell and animal rejuvenation.”
Financial supporters for this research include National Agency for the Promotion of Science and Technology, Medical Research Charitable Foundation, Society for Experimental Gerontological Research, New Zealand.
Our news editors obtained a quote from the research from the National University of La Plata, “Then, a comparison will be made between the principles of the cumulative DNA damage theory of aging and the basic facts underlying the epigenetic model of aging, including Horvath’s epigenetic clock. The third part will apply both models to two natural processes, namely, the setting of the aging clock in the mammalian zygote and the changes in the aging clock along successive generations in mammals. The first study demonstrating that skin fibroblasts from healthy centenarians can be rejuvenated by cell reprogramming was published in 2011 and will be discussed in some detail. Other cell rejuvenation studies in old humans and rodents published afterwards will be very briefly mentioned. The only in vivo study reporting that a number of organs of old progeric mice can be rejuvenated by cyclic partial reprogramming will also be described in some detail. The cumulative DNA damage theory of aging postulates that as an animal ages, toxic reactive oxygen species generated as byproducts of the mitochondria during respiration induce a random and progressive damage in genes thus leading cells to a progressive functional decline. The epigenetic model of aging postulates that there are epigenetic marks of aging that increase with age, leading to a progressive derepression of DNA which in turn causes deregulated expression of genes that disrupt cell function. The cumulative DNA damage model of aging fails to explain the resetting of the aging clock at the time of conception as well as the continued vitality of species as millenia go by. In contrast, the epigenetic model of aging straightforwardly explains both biologic phenomena. A plausible initial application of rejuvenation in vivo would be preventing adult individuals from aging thus eliminating a major risk factor for end of life pathologies.”
According to the news editors, the research concluded: “Further, it may allow the gradual achievement of whole body rejuvenation.”
For more information on this research see: Rejuvenation By Cell Reprogramming: a New Horizon In Gerontology. Stem Cell Research & Therapy, 2018;9():. Stem Cell Research & Therapy can be contacted at: Bmc, Campus, 4 Crinan St, London N1 9XW, England. (BioMed Central - http://www.biomedcentral.com/; Stem Cell Research & Therapy - stemcellres.com)
The news editors report that additional information may be obtained by contacting R.G. Goya, National University, School of Medicine, Inst Biochem Res Inibiolp Histol B & Pathol B, Cc 455, Ra-1900 La Plata, Buenos Aires, Argentina. Additional authors for this research include M. Lehmann, P. Chiavellini, M. Canatelli-Mallat, O.A. Brown and C.B. Herenu.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1186/s13287-018-1075-y. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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