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Findings on Oxidative Medicine and Cellular Longevity Described by Researchers at First Affiliated Hospital of Soochow University (Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA ...)

Hospital & Nursing Home Daily

06-19-19

2019 JUN 05 (NewsRx) -- By a News Reporter-Staff News Editor at Hospital & Nursing Home Daily -- Investigators discuss new findings in Health and Medicine - Oxidative Medicine and Cellular Longevity. According to news reporting out of Suzhou, People’s Republic of China, by NewsRx editors, research stated, “Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-B and TNF-have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-B and TNF-remain unknown.”

Financial support for this research came from Priority Academic Program Development of Jiangsu Higher Education Institutions.

Our news journalists obtained a quote from the research from the First Affiliated Hospital of Soochow University, “Exosomes have been reported to improve heart functions by releasing miRNA. Recent studies suggest that lncRNAs are more tissue-specific and developmental stage-specific compared to miRNA. However, the role of lncRNA in exosome-mediated cardiac repair has not been explored. In the present study, we focused on metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which is an lncRNA associated with cell senescence. We discovered that human umbilical cord mesenchymal stem cell-(UMSC-) derived exosomes prevent aging-induced cardiac dysfunction. Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes. In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits the NF-B/TNF-signaling pathway.”

According to the news editors, the research concluded: “These findings will lead to the development of therapies that delay aging and progression of age-related diseases.”

For more information on this research see: Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-kB/TNF-a Signaling Pathway. Oxidative Medicine and Cellular Longevity, 2019;2019():1-14. (Hindawi Publishing - www.hindawi.com; Oxidative Medicine and Cellular Longevity - http://www.hindawi.com/journals/oximed/)

Our news journalists report that additional information may be obtained by contacting B. Zhu, Institute for Cardiovascular Science & Dept. of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, People’s Republic of China. Additional authors for this research include L. Zhang, C. Liang, B. Liu, X. Pan, Y. Wang, Y. Zhang, Y. Zhang, W. Xie, B. Yan, F. Liu, H.K. Yip, X.Y. Yu and Y. Li.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1155/2019/9739258. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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