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Researchers at Air Force Medical University Have Reported New Data on Cardiomyopathies (Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy By Attenuating High Glucose-induced Oxidative Stress and Fibrosis Via Activating the Sirt1 Pathway)

Defense & Aerospace Daily

06-19-19

2019 JUN 18 (NewsRx) -- By a News Reporter-Staff News Editor at Defense & Aerospace Daily -- New research on Heart Disorders and Diseases - Cardiomyopathies is the subject of a report. According to news reporting from Xi’an, People’s Republic of China, by NewsRx journalists, research stated, “Hyperglycemia-induced oxidative stress and fibrosis play a crucial role in the development of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite of natural antioxidant curcumin, is reported to exert even more effective antioxidative and superior antifibrotic properties as well as anti-inflammatory and antidiabetic abilities.”

Financial supporters for this research include Science and Technology Innovation Project of Shaanxi Province in China, Key Research Laboratory of Traditional Chinese Medicine and Natural Medicine in Shaanxi Province, Shaanxi Engineering Technology Research Center, National Key Research and Development Program of China, National Natural Science Foundation of China, Science and Technology Research and Development Program of Shaanxi Province, High and New Technology Project of Xijing Hospital.

The news correspondents obtained a quote from the research from Air Force Medical University, “This study was designed to investigate the potential protective effects of THC on experimental DCM and its underlying mechanisms, pointing to the role of high glucose-induced oxidative stress and interrelated fibrosis. In STZ-induced diabetic mice, oral administration of THC (120 mg/kg/d) for 12 weeks significantly improved the cardiac function and ameliorated myocardial fibrosis and cardiac hypertrophy, accompanied by reduced reactive oxygen species (ROS) generation. Mechanically, THC administration remarkably increased the expression of the SIRT1 signaling pathway both in vitro and in vivo, further evidenced by decreased downstream molecule Ac-SOD2 and enhanced deacetylated production SOD2, which finally strengthened antioxidative stress capacity proven by repaired activities of SOD and GSH-Px and reduced MDA production. Additionally, THC treatment accomplished its antifibrotic effect by depressing the ROS-induced TGF beta 1/Smad3 signaling pathway followed by reduced expression of cardiac fibrotic markers a-SMA, collagen I, and collagen III.”

According to the news reporters, the research concluded: “Collectively, these finds demonstrated the therapeutic potential of THC treatment to alleviate DCM mainly by attenuating hyperglycemia-induced oxidative stress and fibrosis via activating the SIRT1 pathway.”

For more information on this research see: Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy By Attenuating High Glucose-induced Oxidative Stress and Fibrosis Via Activating the Sirt1 Pathway. Oxidative Medicine and Cellular Longevity, 2019;():. Oxidative Medicine and Cellular Longevity can be contacted at: Hindawi Ltd, Adam House, 3RD Flr, 1 Fitzroy Sq, London, W1T 5HF, England. (Hindawi Publishing - www.hindawi.com; Oxidative Medicine and Cellular Longevity - http://www.hindawi.com/journals/oximed/)

Our news journalists report that additional information may be obtained by contacting S.W. Wang, Air Force Medical University, School of Pharmacy, Dept Chinese Mat Med & Nat Med, Xian 710032, Shaanxi, People’s Republic of China. Additional authors for this research include K.F. Li, F. Song, J. Li, H. Li, L. Xu, Y. Cao, M.S. He, M.G. Zhai, L.Q. Jiang, B. Zhang, B.Y. Li, L. Xia, H.Z. Zhu, L.Y. Zhang, H.L. Liang, Z.X. Jin and W.X. Duan.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1155/2019/6746907. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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