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Study Findings from Kaohsiung Medical University Hospital Provide New Insights into Head and Neck Cancer (Influence of Tea Consumption On the Development of Second Esophageal Neoplasm In Patients With Head and Neck Cancer)

Taiwan Daily Report


2019 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Taiwan Daily Report -- Data detailed on Oncology - Head and Neck Cancer have been presented. According to news reporting originating from Kaohsiung, Taiwan, by NewsRx correspondents, research stated, “Alcohol is an important risk factor for the development of second esophageal squamous-cell carcinoma (ESCC) in head and neck squamous-cell carcinoma (HNSCC) patients. However, the influence of tea consumption is uncertain.”

Funders for this research include Taiwan’s Ministry of Science and Technology, Kaohsiung Medical University Hospital, Health and Welfare surcharge of tobacco products, NSYSU-KMU Joint Research Project.

Our news editors obtained a quote from the research from Kaohsiung Medical University Hospital, “We prospectively performed endoscopic screening in incident HNSCC patients to identify synchronous esophageal neoplasm. In total, 987 patients enrolled between October 2008 and December 2017 and were analyzed. In vitro studies were conducted to investigate the effect of epigallocatechin gallate (EGCG) on the betel alkaloid, arecoline-stimulated carcinogenesis in two ESCC cell lines. There were 151 patients (15.3%) diagnosed to have synchronous esophageal neoplasm, including 88 low-grade dysplasia, 30 high-grade dysplasia and 33 squamous-cell carcinoma (SCC). Tea consumption was associated with a significantly lower risk of having esophageal high-grade dysplasia or SCC in HNSCC patients, especially those who were betel nut chewers, alcohol drinkers or cigarette smokers (all adjusted odds ratio were 0.5; p-values: 0.045, 0.045 and 0.049 respectively). In vitro studies indicated that EGCG suppressed arecoline-induced ESCC cell proliferation and colony formation through the inhibition of the Akt and ERK1/2 pathway in a reactive oxygen species-independent manner.”

According to the news editors, the research concluded: “Tea consumption may protect against the development of second esophageal neoplasms among HNSCC patients, especially those who regularly consume betel nuts, alcohol and cigarettes.”

For more information on this research see: Influence of Tea Consumption On the Development of Second Esophageal Neoplasm In Patients With Head and Neck Cancer. CANCERS, 2019;11(3):. CANCERS can be contacted at: Mdpi, St Alban-Anlage 66, Ch-4052 Basel, Switzerland.

The news editors report that additional information may be obtained by contacting I.C. Wu, Kaohsiung Medical University Hospital, Division of Gastroenterology, Dept. of Internal Medicine, Kaohsiung 80708, Taiwan. Additional authors for this research include Y.K. Wang, Y.H. Chen, W.C. Chen, Y.H. Lai, M.T. Wu, Y.P. Liu, C.T. Kuo, Y.Y. Wang and S.S.F. Yuan.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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