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Reports from University of Shandong Describe Recent Advances in Vitamin D Deficiency (Vitamin D Deficiency As a Risk Factor for Thyroid Cancer: a Meta Analysis of Case-control Studies)

Disease Prevention Daily


2019 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Current study results on Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency have been published. According to news reporting from Jinan, People’s Republic of China, by NewsRx journalists, research stated, “The association between vitamin D deficiency and thyroid cancer is controversial. Some studies have demonstrated that high er serum vitamin D levels might protect against thyroid cancer, whereas others have not, or have even indicated the opposite to be the case.”

Funders for this research include Medical and Health Technology Development Program in Shandong province, National Natural Science Foundation of China, Shandong Provincial Natural Science Foundation of China, grant for the development of science and technology of Jinan City.

The news correspondents obtained a quote from the research from the University of Shandong, “The aim of this meta-analysis was to investigate the association between vitamin D deficicency and thyroid cancer and propose that vitamin D deficiency is a risk factor for thyroid cancer. This was a meta-analysis of 14 articles of the association between vitamin D deficiency and thyroid cancer. Databases including PubMed, Cochrane library, Sinomed, CNKI, Wanfang, and clinical trial register centers, were searched for case-control studies of vitamin D in thyroid cancer. Fourteen studies were included in this meta-analysis. A fixed-effect model was used to merge the standardized mean difference value of serum 25-hydroxyvitamin D levels. The pooled effect showed that the levels of serum 25-hydroxyvitamin D were lower in patients with thyroid cancer preoperatively than in the controls (-0.22; 95% confidence interval [CI], -0.36 to -0.09; P = 0.001). There was no difference after thyroid cancer patients underwent thyroidectomy (-0.19; 95% CI, -0.47 to 0.10; P = 0.21). A fixed-effect model was used to pool the odds ratio of thyroid cancer and vitamin D deficiency. It showed that the pooled odds ratio from six studies was 1.30 (95% CI, 1.00-1.69; P = 0.05). Subgroup analysis of 25-hydroxyvitamin D levels between different pathologic characteristics in patients with thyroid cancer was summarized, but no statistical differences were determined. Lower serum 25-hydroxyvitamin D levels were associated with increased risk for thyroid cancer.”

According to the news reporters, the research concluded: “On the other hand, vitamin D deficiency may act as a risk factor for thyroid cancer.”

For more information on this research see: Vitamin D Deficiency As a Risk Factor for Thyroid Cancer: a Meta Analysis of Case-control Studies. Nutrition, 2019;57():5-11. Nutrition can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Nutrition -

Our news journalists report that additional information may be obtained by contacting L. Liao, University of Shandong, Shandong Provincial Qianfoshan Hospital, Dept. of Endocrinology, Jinan, Shandong, People’s Republic of China. Additional authors for this research include J.Y. Zhao, Z.W. Zhang, X.J. Zhou, J.M. Yao, R. Zhang, H.P. Wang and J.J. Dong.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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