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Researchers from Research Center of Neurology Report Findings in Ischemia (Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine)

Genomics & Genetics Daily

07-10-19

2019 JUL 09 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Researchers detail new data in Vascular Diseases and Conditions - Ischemia. According to news reporting originating in Moscow, Russia, by NewsRx journalists, research stated, “Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxidant activity was by 25% higher than in other areas.”

The news reporters obtained a quote from the research from the Research Center of Neurology, “During ischemia, changes in oxidative status were localized only in the ischemic focus and penumbra zone and did not involve other cortical areas. We demonstrated for the first time a neuroprotective effect of therapeutic administration of carnosine in low doses (50 mg/kg) on parameters of the oxidative status under conditions of focal ischemia comparable to its effect of high doses (500 mg/kg) as well as its local effect in the penumbra zone. A dose-dependent effect of carnosine on antioxidant activity in the penumbra zone during ischemia was also demonstrated.”

According to the news reporters, the research concluded: “These findings confirm effectiveness of not only preventive carnosine administration, but also its application in the postischemic period of the stroke.”

For more information on this research see: Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine. Bulletin of Experimental Biology and Medicine, 2018;165(6):746-750. Bulletin of Experimental Biology and Medicine can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Bulletin of Experimental Biology and Medicine - http://www.springerlink.com/content/0007-4888/)

Our news correspondents report that additional information may be obtained by contacting T.N. Fedorova, Research Center of Neurology, Moscow, Russia. Additional authors for this research include A.A. Devyatov, D.S. Berezhnoi, S.L. Stvolinskii, M.P. Morozova, S.A. Gavrilova and V.A. Tutelyan.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s10517-018-4256-x. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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