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New Vitamin D Deficiency Findings from Massachusetts General Hospital Reported (Temporal Increases In 25-hydroxyvitamin D In Midlife Women: Longitudinal Results From the Study of Women’s Health Across the Nation)

NewsRx Women’s Health Daily


2019 JUL 09 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women’s Health Daily -- Fresh data on Nutritional and Metabolic Diseases and Conditions - Vitamin D Deficiency are presented in a new report. According to news originating from Boston, United States, by NewsRx correspondents, research stated, “Objective 25-hydroxyvitamin D (25(OH)D) is critical for bone mineralization and may prevent fractures. Understanding vitamin D deficiency trends in midlife women is particularly important given their concurrent menopausal changes that increase risk for fracture.”

Financial support for this research came from NIH.

Our news journalists obtained a quote from the research from Massachusetts General Hospital, “We aimed to evaluate changes in mean 25(OH)D over time and their determinants in a racially, ethnically and socioeconomically diverse cohort of midlife women. A multi-centre prospective cohort study. Patients 1585 women ages 42-52 years at baseline. We measured serum 25(OH)D at 2 time points (1998-2000 and 2009-2011). Between-visit change was assessed in the whole cohort and in socioeconomic and demographic subgroups. Among those with vitamin D deficiency (25(OH)D <30 nmol/L) at baseline, we evaluated determinants of persistent deficiency at follow-up. Mean 25(OH)D increased from 53.8 to 70.0 nmol/L (P < 0.001), and the prevalence of deficiency decreased from 20.4% to 9.7% (P < 0.001). While baseline 25(OH)D differed among subgroups, the changes in 25(OH)D were similar among groups. The proportion of women reporting dietary supplement use increased from 40.8% to 67.1% (P < 0.001), and the increase in 25(OH)D was significantly higher in supplement users. Among women with vitamin D deficiency at baseline, White women and supplement users were less likely to remain deficient at follow-up. Among midlife women, temporal increases in 25(OH)D concentrations are driven largely by increases in supplement use. The proportion of women with 25(OH)D <30 nmol/L and thus at high risk for skeletal consequences remains substantial.”

According to the news editors, the research concluded: “Targeted screening for vitamin D deficiency in populations at risk for fragility fracture may be advisable.”

For more information on this research see: Temporal Increases In 25-hydroxyvitamin D In Midlife Women: Longitudinal Results From the Study of Women’s Health Across the Nation. Clinical Endocrinology, 2019;91(1):48-57. Clinical Endocrinology can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Clinical Endocrinology -

The news correspondents report that additional information may be obtained from D.M. Mitchell, School of Medicine, Massachusetts General Hospital, Endocrine Unit, Boston, MA 02115, United States. Additional authors for this research include N. Udupa, F. Bassir, K. Darakananda, J.S. Finkelstein, S.A.M. Burnett-Bowie, K. Ruppert, Y.J. Lian, J.A. Cauley, D.H. Solomon, A.S. Karlamangla and G.A. Greendale.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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