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Studies from Tabriz University of Medical Sciences Yield New Data on Complementary and Alternative Medicine (Effect of vitamin E on severity and duration of cyclic mastalgia: A systematic review and meta-analysis)

Fitness & Wellness Daily


2019 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at Fitness & Wellness Daily -- New research on Health and Medicine - Complementary and Alternative Medicine is the subject of a report. According to news reporting out of Tabriz, Iran, by NewsRx editors, research stated, “A systematic review was conducted to assess the effect of vitamin E on the severity and duration of Cyclic Mastalgia compared to vitamin B6, fish oil, herbal medicines and placebo. A systematic review and meta-analysis of clinical trials.”

Our news journalists obtained a quote from the research from the Tabriz University of Medical Sciences, “A search was carried out in PubMed, Cochrane Library, Embase, Scopus and Google Scholar and Persian databases for articles published from 1980 to 2018. The data obtained were analyzed in RevMan and reported in forest plots. The Odds Ratio (OR) was used to find the effect for the dichotomous data and the Standardized Mean Difference (SMD) for the continuous data. The heterogeneity of the studies was assessed using I-2 and the Random Effects Model was used instead of the Fixed Effects Model if I-2 > 25%. A total of 1051 titles and abstracts were extracted. Fourteen articles ultimately remained, and 11 of them were entered into the meta-analysis. The meta-analysis showed significant differences between vitamin E and placebo in the severity (SMD = -0.51; 95% CI= - 0.21 to -0.82) and duration (MD = -1.47; 95% CI= - 0.91 to 2.57) of cyclic mastalgia, although herbal medicines had a greater effect on the severity of mastalgia than vitamin E (SMD = 0.51, 95% CI = 0.06 to 0.96). Although herbal medicines are more effective than vitamin E, vitamin E reduces both the severity and duration of the disorder compared to placebos, which only reduce its severity, and can therefore be considered a treatment with minimum side-effects.”

According to the news editors, the research concluded: “Due to the high heterogeneity of the studies, the researchers recommend further research on the subject using a standard tool based on the CONSORT statement.”

For more information on this research see: Effect of vitamin E on severity and duration of cyclic mastalgia: A systematic review and meta-analysis. Complementary Therapies in Medicine, 2019;44():1-8. Complementary Therapies in Medicine can be contacted at: Churchill Livingstone, Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh EH1 3AF, Midlothian, Scotland. (Elsevier -; Complementary Therapies in Medicine -

Our news journalists report that additional information may be obtained by contacting M. Mirghafourvand, Tabriz University of Medical Sciences, Social Determinants Hlth Res Ctr, Tabriz, Iran. Additional authors for this research include K. Hajizadeh, R. Hasanzade and S.M.A. Charandabi.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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