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Research from Carlos III Institute of Health Reveals New Findings on Psychopharmacology (Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people)

Information Technology Daily


2019 JUL 09 (NewsRx) -- By a News Reporter-Staff News Editor at Information Technology Daily -- Investigators publish new report on Drugs and Therapies - Psychopharmacology. According to news reporting from Madrid, Spain, by NewsRx journalists, research stated, “Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors. To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.”

Financial supporters for this research include Instituto de Salud Carlos III, The Queen Sofia Foundation.

The news correspondents obtained a quote from the research from the Carlos III Institute of Health, “Medication intake was recorded during two years in 1087 individuals 70-85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years was ascertained by cross-sectional and longitudinal analyses controlling for demographic and clinical variables. Small effects of several drugs on information processing were found in cross-sectional analyses but only confirmed for a positive effect of vitamin D in case-control analyses. Longitudinal analyses showed no drug effects on the cognitive slopes. Several hypotensive drugs reduced, whereas bromazepam and glucose lowering drugs increased, the conversion rate to mild cognitive impairment with very small effects (=0.3-1%). Cognitively healthy elderly individuals show minimal negative effects on information processing associated with chronic intake of some drugs probably related to the subjacent condition. Some drugs slightly affect the rate of conversion to mild cognitive impairment.”

According to the news reporters, the research concluded: “Positive effects of vitamin D, chondroitin, atorvastatin and antihypertensive drugs, and negative effects of antidepressants and benzodiazepines, should be further explored in studies with longer follow-up.”

For more information on this research see: Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people. Journal of Psychopharmacology, 2019;():026988111985720. Journal of Psychopharmacology can be contacted at: SAGE Publications, USA , 2455 Teller Road, Thousand Oaks, CA 91320, USA. (Sage Publications -; Journal of Psychopharmacology -

Our news journalists report that additional information may be obtained by contacting T. Del Ser, 1 Alzheimer’s Disease Investigation Research Unit, CIEN Foundation, Carlos III Institute of Health, Queen Sofia Foundation, Alzheimer Research Centre, Madrid, Spain. Additional authors for this research include M.A. Zea, M. Valenti, J. Olazaran, J. Lopez-Alvarez, A. Rebollo-Vazquez, M. Avila-Villanueva, B. Frades, M. Medina and M.A Fernandez-Blazquez.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the Journal of Psychopharmacology is: SAGE Publications, USA , 2455 Teller Road, Thousand Oaks, CA 91320, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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