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Study Results from University of Alexandria in the Area of Amyloid Reported (Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid b accumulation in a rat model of Alzheimer’s disease)

Health & Medicine Daily

07-15-19

2019 JUL 12 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Research findings on Peptides and Proteins - Amyloid are discussed in a new report. According to news reporting from Alexandria, Egypt, by NewsRx journalists, research stated, “Oxidative stress and neuroinflammatory changes appear to be the early events involved in AD’s development and progression. The present study was designed to assess the effect of soybean isoflavone extract (SIFE) against colchicine-induced cognitive dysfunction and oxidative stress in male rats.Fifty adult male Wistar albino rats were divided into five groups: control, ACSF-treated group, soybean isoflavones (SIF)-treated group, colchicine (COL)-treated group, and SIF + COL-treated group.”

The news correspondents obtained a quote from the research from the University of Alexandria, “We found that an intracerebroventricular (icv) injection of a single dose of colchicine (7.5 mg/rat bilaterally) resulted in learning deficits in rats subjected to the Morris water maze task associated with marked oxidative damage and decreased acetyl cholinesterase (AChE) activity. In addition, COL caused significant increase in amyloid beta peptide 1-42 (b, amyloid 1-42) interleukin-1b (IL-1b), tumor necrosis factor-a (TNFa), cyclooxygenase-2 (COX-2) and TNF-a genes expression in the brain, and glial fibrillary acidic protein (GFAP) in cortical astrocytes in the brain cortex.Treatment with SIFE (80 mg/kg b.wt) daily for 14 days followed by a single dose of COL significantly reduced the elevated oxidative stress parameters and restored the reduced antioxidant activities. Besides, the administration of SIFE reversed the overproduction of b, amyloid 1-42, pro-inflammatory cytokines, and GFAP in the brain.”

According to the news reporters, the research concluded: “The obtained results were confirmed by histological observations that clearly indicate a neuroprotective effect of SIF against AD.”

For more information on this research see: Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid b accumulation in a rat model of Alzheimer’s disease. Environmental Science and Pollution Research International, 2019;():. Environmental Science and Pollution Research International can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

Our news journalists report that additional information may be obtained by contacting H.M. Abdou, Dept. of Zoology, Faculty of Science, University of Alexandria, Alexandria, Egypt. Additional authors for this research include H.M. Abdou, H.M. Ibrahim and N.M Bouthahab.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s11356-019-05862-z. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

Publisher contact information for the journal Environmental Science and Pollution Research International is: Springer, 233 Spring Street, New York, NY 10013, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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