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Research Results from Seoul National University Hospital Update Knowledge of Dementia (Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment)

Hospital & Nursing Home Daily


2019 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at Hospital & Nursing Home Daily -- Fresh data on Neurodegenerative Diseases and Conditions - Dementia are presented in a new report. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, “This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the ‘Korean Longitudinal Study on Cognitive Aging and Dementia.’ The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables.”

Our news journalists obtained a quote from the research from Seoul National University Hospital, “The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. The lowest quartile group of serum folate (1.5, 5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia.”

According to the news editors, the research concluded: “Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status.”

For more information on this research see: Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment. Psychiatry Investigation, 2019;16(7):532-538.

Our news journalists report that additional information may be obtained by contacting S. Jang, Dept. of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea. Additional authors for this research include J.W. Han, J. Shin, T.H. Kim, K.P. Kwak, K. Kim, B.J. Kim, S.G. Kim, J.L. Kim, T.H. Kim, S.W. Moon, J.Y. Park, J.H. Park, S. Byun, S.W. Suh, J. Seo, Y. So, S.H. Ryu, J.C. Youn, K.H. Lee, D.Y. Lee, D.W. Lee, S.B. Lee and .

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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