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Findings from University of Athens Update Knowledge of Postmenopausal Osteoporosis (Red wine polyphenols modulate bone loss in the ovariectomized rat model of postmenopausal osteoporosis)

Health & Medicine Daily


2019 AUG 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- New research on Metabolic Bone Diseases and Conditions - Postmenopausal Osteoporosis is the subject of a report. According to news reporting from Athens, Greece, by NewsRx journalists, research stated, “The aim of this study was to examine the effect of Red Wine Polyphenols (RWPs) extract on bone mineral density (BMD) in the ovariectomized (OVX) rat model. Thirty-five 10-month-old Wistar rats were separated into controls (CTRL), OVX and OVX plus RWPs in their drinking water (dose, 50 mg/kg body weight per day), starting immediately after OVX for 6 months.”

The news correspondents obtained a quote from the research from the University of Athens, “Body and uterine weight, BMD of the tibia at baseline, 3 and 6 months post-OVX, and 3-pointing bending of the femur, were examined. Statistical comparison of the total tibia BMD within groups during the study period showed a significant reduction in the OVX and OVX+RWPs groups both from baseline to 3 and 6 months and from 3 to 6 months, whereas in the CTRL group, there was no significant change. For the proximal tibial metaphysic, comparison of BMD percentage changes from baseline to 3 months and 6 months and from 3 to 6 months revealed highly statistical differences between OVX and OVX+RWPs groups (P = 0.000). OVX induced a significant reduction of biomechanical parameters as expected; the 3-point bending test showed that the maximum force before fracture, energy absorption and fracture stress significantly increased in the OVX group treated with RWPs compared with the nontreated OVX rats (P = 0.048, P = 0.002 and P = 0.003, respectively).”

According to the news reporters, the research concluded: “Dietary intake of RWPs for 6 months significantly prevented trabecular bone loss and improved bone strength in estrogen-deficient ovariectomized rats.”

For more information on this research see: Red wine polyphenols modulate bone loss in the ovariectomized rat model of postmenopausal osteoporosis. Journal of the Hellenic Veterinary Medical Society, 2019;70(2):1541. Journal of the Hellenic Veterinary Medical Society can be contacted at: Hellenic Veterinary Medical Soc, 158 Patission St, Athens, 112 57, Greece.

Our news journalists report that additional information may be obtained by contacting C. Passali, University of Athens, School of Medicine, Lab Res Musculoskeletal Syst, Athens, Greece. Additional authors for this research include A. Patsaki, P. Lelovas, N. Papaioannou, I. Dontas, N. Aligiannis, M. Makropoulou, S. Mitakou, A.L. Skaltsounis and S. Kourkoulis.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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