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Researchers’ Work from China Medical University and Hospital Focuses on Alzheimer Disease (The Model of Aging Acceleration Network Reveals the Correlation of Alzheimer’s Disease and Aging at System Level)

Hospital & Nursing Home Daily

08-23-19

2019 AUG 20 (NewsRx) -- By a News Reporter-Staff News Editor at Hospital & Nursing Home Daily -- Current study results on Neurodegenerative Diseases and Conditions - Alzheimer Disease have been published. According to news originating from Shenyang, People’s Republic of China, by NewsRx correspondents, research stated, “As the incidence of senile dementia continues to increase, researches on Alzheimer’s disease (AD) have become more and more important. Several studies have reported that there is a close relationship between AD and aging.”

Financial support for this research came from China Postdoctoral Science Foundation.

Our news journalists obtained a quote from the research from China Medical University and Hospital, “Some researchers even pointed out that if we wanted to understand AD in depth, mechanisms of AD based on accelerated aging must be studied. Nowadays, machine learning techniques have been utilized to deal with large and complex profiles, thus playing an important role in disease researches (i.e., modelling biological systems, identifying key modules based on biological networks, and so on). Here, we developed an aging predictor and an AD predictor using machine learning techniques, respectively. Both aging and AD biomarkers were identified to provide insights into genes associated with AD. Besides, aging scores were calculated to reflect the aging process of brain tissues. As a result, the aging acceleration network and the aging-AD bipartite graph were constructed to delve into the relationship between AD and aging. Finally, a series of network and enrichment analyses were also conducted to gain further insights into the mechanisms of AD based on accelerated aging.”

According to the news editors, the research concluded: “In a word, our results indicated that aging may contribute to the development of AD by affecting the function of the immune system and the energy metabolism process, where the immune system may play a more prominent role in AD.”

For more information on this research see: The Model of Aging Acceleration Network Reveals the Correlation of Alzheimer’s Disease and Aging at System Level. Biomed Research International, 2019;2019():1-11.

The news correspondents report that additional information may be obtained from M. Zhou, Dept. of Biomedical Engineering, School of Fundamental Sciences, China Medical University and Hospital, Shenyang 110122, Liaoning Province, People’s Republic of China. Additional authors for this research include X. Xia, H. Yan, S. Li, S. Bian, X. Sha and Y. Wang.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1155/2019/4273108. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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