Study Results from Kindai University Broaden Understanding of Colon Cancer (A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells)
Genomics & Genetics Daily
2019 SEP 09 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Research findings on Oncology - Colon Cancer are discussed in a new report. According to news reporting originating from Fukuoka, Japan, by NewsRx correspondents, research stated, “Resveratrol, a phytoalexin present in grapes and other edible foods, has been reported to have beneficial effects against various diseases including cancer. We previously reported that resveratrol and its derivative, caffeic acid-adducted resveratrol, selectively inhibit the three-dimensional (3D) proliferation of a human colorectal cancer cell line, HCT116 with activating KRAS mutation.”
Financial supporters for this research include Naito Foundation, JSPS KAKENHI.
Our news editors obtained a quote from the research from Kindai University, “Herein, we demonstrated that a novel compound, ferulic acid-bound resveratrol, also represses the 3D proliferation of HCT116 cells. We observed that resveratrol conjugated to two ferulic acids represses the 3D proliferation of HCT116 cells more strongly than resveratrol and resveratrol conjugated to one ferulic acid. Resveratrol conjugated to two ferulic acids also inhibited the 3D proliferation of MCF7 human breast cancer cells. We further uncovered that the resveratrol derivative increases the mRNA level of the tumor suppressor p15, a CDK inhibitor that functions as a brake of cell proliferation in HCT116 cells.”
According to the news editors, the research concluded: “These results imply that the resveratrol derivative represses 3D proliferation via increasing p15 expression in HCT116 cells.”
For more information on this research see: A novel compound, ferulic acid-bound resveratrol, induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells. Molecular and Cellular Biochemistry, 2019;():. Molecular and Cellular Biochemistry can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Molecular and Cellular Biochemistry - http://www.springerlink.com/content/0300-8177/)
The news editors report that additional information may be obtained by contacting Y. Kotake, Graduate School of Humanity-Oriented Science and Engineering, Kindai University, 11-6 Kayanomori, Iizuka, Fukuoka, 820-8555, Japan. Additional authors for this research include T. Matsukawa, S. Doi, T. Tsunoda, N. Arikawa, N. Matsunaga, K. Ohnuki, S. Shirasawa and Y. Kotake.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s11010-019-03606-8. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
Publisher contact information for the journal Molecular and Cellular Biochemistry is: Springer, 233 Spring Street, New York, NY 10013, USA.
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