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Findings from University of Oklahoma Health Sciences Center Provide New Insights into Geriatrics and Gerontology///Geriatrics and Gerontology///Geriatrics and Gerontology

Disease Prevention Daily

09-10-19

2019 SEP 09 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- Research findings on Aging Research - Geriatrics and Gerontology are discussed in a new report. According to news originating from Oklahoma City, United States, by NewsRx correspondents, research stated, “Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion.”

Funders for this research include National Institute of Neurological Disorders and Stroke, National Institute on Aging.

Our news journalists obtained a quote from the research from the University of Oklahoma Health Sciences Center, “Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide mononucleotide (NMN) exerts significant vasoprotective effects, improving endothelium-dependent vasodilation, attenuating oxidative stress, and rescuing age-related changes in gene expression. Strong experimental evidence shows that dysregulation of microRNAs (miRNAs) has a role in vascular aging. The present study was designed to test the hypothesis that age-related NAD+ depletion is causally linked to dysregulation of vascular miRNA expression. A corollary hypothesis is that functional vascular rejuvenation in NMN-treated aged mice is also associated with restoration of a youthful vascular miRNA expression profile. To test these hypotheses, aged (24-month-old) mice were treated with NMN for 2 weeks and miRNA signatures in the aortas were compared to those in aortas obtained from untreated young and aged control mice. We found that protective effects of NMN treatment on vascular function are associated with anti-aging changes in the miRNA expression profile in the aged mouse aorta. The predicted regulatory effects of NMN-induced differentially expressed miRNAs in aged vessels include anti-atherogenic effects and epigenetic rejuvenation.”

According to the news editors, the research concluded: “Future studies will uncover the mechanistic role of miRNA gene expression regulatory networks in the anti-aging effects of NAD+ booster treatments and determine the links between miRNAs regulated by NMN and sirtuin activators and miRNAs known to act in the conserved pathways of aging and major aging-related vascular diseases.”

For more information on this research see: Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. Geroscience, 2019;():.

The news correspondents report that additional information may be obtained from Z. Ungvari, Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Dept. of Geriatric Medicine, University of Oklahoma, 975 NE 10th Street, BRC 1311, Oklahoma City, OK 73104, United States. Additional authors for this research include C.B. Giles, S. Tarantini, A. Yabluchanskiy, P. Balasubramanian, T. Gautam, T. Csipo, A. Nyul-Toth, A. Lipecz, C. Szabo, E. Farkas, J.D. Wren, A. Csiszar and Z. Ungvari.

The direct object identifier (DOI) for that additional information is: https://doi.org/10.1007/s11357-019-00095-x. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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