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Investigators from Hannover Medical School Report New Data on Cell Physiology (Role of Vitamin D In Cell-cell Interaction of Fetal Endothelial Progenitor Cells and Umbilical Cord Endothelial Cells In a Preeclampsia-like Model)

NewsRx Women’s Health Daily


2019 SEP 10 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women’s Health Daily -- Fresh data on Life Science Research - Cell Physiology are presented in a new report. According to news reporting originating in Hannover, Germany, by NewsRx journalists, research stated, “Maternal endothelial dysfunction is a cental feature of preeclampsia (PE), a hypertensive disorder of pregnancy. Factors in the maternal circulation are thought to contribute to this endothelial dysfunction.”

Financial support for this research came from German Research Foundation (DFG).

The news reporters obtained a quote from the research from Hannover Medical School, “Although understudied, factors in the fetal circulation may influence fetal endothelial cell interactions with endothelial progenitor cells as critical steps in placental angiogenesis. We hypothesize that cell-cell interactions that are important for pregnancy health are impaired by fetal serum from PE pregnancies and that 1.25(OH)(2)-vitamin D-3 attenuates the negative effects of this serum on cell function. We tested the ability of fetal cord blood-derived endothelial progenitor cells [endothelial colony-forming cells (ECFCs)] to invade into established monolayers and capillary tubule-like structures of human fetal umbilical venous endothelial cells (HUVECs), while in the presence/absence of fetal cord serum from uncomplicated or PE pregnancies, and tested the ability of 1,25(OH)(2)-vitamin D-3 to modulate the serum-mediated effects. PE cord serum reduced the invasion of fetal ECFCs into HUVEC monolayers or tubule networks. Vitamin D attenuated these effects of PE fetal serum on endothelial functional properties. Immunocytochemical studies revealed involvement of VE-cadherin contacts in interactions between ECFCs and mature fetal endothelial cells. PE cord serum reduces the ability of fetal endothelial progenitor cells to incorporate into fetal endothelial cell networks. Physiologic concentrations of vitamin D reverse these PE serum-mediated effects.”

According to the news reporters, the research concluded: “These data appear consistent with lines of evidence that vitamin D has antipreeclampsia effects.”

For more information on this research see: Role of Vitamin D In Cell-cell Interaction of Fetal Endothelial Progenitor Cells and Umbilical Cord Endothelial Cells In a Preeclampsia-like Model. AJP Cell Physiology, 2019;317(2):C348-C357. AJP Cell Physiology can be contacted at: Amer Physiological Soc, 9650 Rockville Pike, Bethesda, MD 20814, USA.

Our news correspondents report that additional information may be obtained by contacting F. Von Versen-Hoynck, Hannover School of Medicine, Dept. of Obstetrics and Gynecology, Hannover, Germany. Additional authors for this research include L. Brodowski, B. Schroder-Heurich, T.H. Vu, C.S. von Kaisenberg and C.A. Hubel.

The direct object identifier (DOI) for that additional information is: This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.

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