Life Extension Update
|Life Extension Update Exclusive |
Study estimates over half of women with osteoporosis are vitamin D deficient
The study analyzed serum 25-hydroxy vitamin D levels in 1,536 postmenopausal women being treated for osteoporosis. 25-hydroxy vitamin D is made by the body from precursors of vitamin D, and indicates the level of vitamin D reserves.
Fifty-two percent of the participants were found to have 25-hydroxy vitamin D levels of less than 30 nanograms per mililter, which the researchers defined as inadequate. Vitamin D inadequacy was significantly more prevalent in women who were taking fewer than 400 international units of vitamin D compared to those who were taking more than this amount.
Director of the Toni Stabile Center for the Prevention and Treatment of Osteoporosis at New York-Presbyterian Hospital/Columbia University Medical Center, Ethel Siris, MD, commented, "While women may know that calcium is an important part of bone health, this research shows that some women on treatment for osteoporosis are unaware of the important role vitamin D plays or are simply not getting adequate amounts as part of their treatment regimen. Getting enough vitamin D, whether through supplements, proper food choices or appropriate and careful exposure to sunlight, is vital to managing osteoporosis."
Female hormone replacement therapy
The benefits of estrogen make it desirable for most menopausal women to maintain youthful levels of this hormone. The question is: can the antiaging benefits of estrogen be obtained without increasing the risk of cancer and arterial blood clots? One alternative to potent hormonal drugs is natural estrogen supplements produced from plant sources. These estrogens are known as "phytoestrogens," and been studied extensively, and may be safer. The literature reveals some interesting findings about plant-derived estrogens. Phytoestrogens from soy reduce hot flashes and protect against age-related diseases such as osteoporosis, heart disease, and cancer (Vincent et al. 2000).
Genistein is one of the active components soy that prevents bone loss in ovariectomized rats. The mechanism of action of genistein (the most abundant soy phytoestrogen) differs from that of estrogens (Fanti et al. 1998). Postmenopausal women received daily either soy protein containing phytoestrogens or milk-derived protein that contained no phytoestrogens. Significant increases in bone density and bone mineral content of the lumbar spine in the women receiving the higher dose of phytoestrogens derived from soy protein diets (which provided 2.25 mg of isoflavones) resulted, but not after milk-derived protein. Soy isoflavones show potential for maintaining bone health (Potter et al. 1998).
In 1998, Leonetti studied the use of over-the-counter natural progesterone cream for the prevention of osteoporosis. The female subjects were immediate post-menopausal (1-5 years after menopause) when bone loss is most rapid. After the first year the positive effects of progesterone were so apparent that the physicians could tell which women were receiving progesterone by the symptoms displayed, including the disappearance of lumps in their breasts, reduced depression, fewer hot flashes, and higher bone densities (although the time interval was too short for the latter to be statistically significant).
No women using progesterone cream had a loss of bone density, whereas the placebo group showed slight bone loss. However, the bone densities did not change significantly (Leonetti, personal communication). Leonetti theorized that the lack of statistical significance may have been because the women were in early menopause when bone loss is highest. During early menopause estrogen deficiency causes the greatest bone loss. The bone-protective effects of progesterone might have been better if the subjects who were estrogen-deficient were given nutrients such as magnesium, zinc, copper, and manganese, along with exercise and low-dose estrogen. One should not expect progesterone alone to protect against age-related loss in bone density.
Vitamin D is necessary for utilization of calcium and phosphorus and in many ways acts as a hormone. The two most important forms of vitamin D are cholecalciferol (D3), which is derived from our own cholesterol and ergocalciferol (D2), a plant analogue derived from the diet. The cholecalciferol supplied by the Life Extension Foundation is synthetic, but its form is identical to that which is derived from cholesterol and synthesized by sunlight on the skin. Cholecalciferol is essential for bone growth and maintenance of bone density.
Suzanne has discovered that the second half of life has been more rewarding, fun, and purposeful than her younger years. The key to her happiness? Taking natural bioidentical hormones. Natural hormones, which mimic the hormones produced in our own bodies that are almost completely lost with aging, are the answer to the symptoms of menopause that plague women. Recent findings from the medical community show that synthetic hormone replacement therapy (HRT) may be harmful to women - thus, thousands of women are looking for what else they can do to alleviate their symptoms. In The Sexy Years, Suzanne comes to the rescue with a step-by-step plan and detailed information about how women can take control of their health, for themselves and for their men.
Questions? Comments? Send them to firstname.lastname@example.org or call 954 766 8433 extension 7716.
For longer life,
Sign up for Life Extension Update at http://mycart.lef.org/subscribe.asp
Help spread the good news about living longer and healthier. Forward this email to a friend!
View previous issues of Life Extension Update in the Newsletter Archive.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.