The May 2005 issue of Cell Metabolism (http://www.cellmetabolism.org/) published an article concerning the discovery by Clay F Semenkovich, MD and colleagues at Washington University School of Medicine in St. Louis that it takes new fat, either obtained from the diet or made in the liver from glucose, to burn the body’s pre-existing fat deposits.
Dr Semenkovich’s team made their discovery by genetically engineering mice to lack a fat-synthesizing enzyme in the liver, rendering them unable to manufacture new fatty acids. When the animals, which are called FASKOL (Fatty Acid Synthase KnockOut in Liver) mice, were provided with a diet that contained no fat, they developed fatty liver disease, a condition that can occur in obese humans, and low blood sugar. Both conditions were reversed when the mice were given diets that contained fat or a drug that activates PPAR-alpha, a protein that is needed to extract energy from carbohydrates and fats. Because the drug elicited the same results as adding fat to the diet, the team concluded that new fat may be necessary to initiating the PPAR-alpha pathway.
Dr Semenkovich, who is a professor of medicine and cell biology and physiology, explained the findings: “When we took dietary fat away from the FASKOL mice, their livers quickly filled with fat. Their 'old' fat stores mobilized to the liver, but their livers could not initiate fat burning, and the fat just accumulated. We concluded that to regulate fat burning, the liver needs 'new' fat."
He added, "Scientists have argued that PPAR-alpha is activated by fats. But we've never known which fats or where they come from. This study suggests that new fat is a 'key' that unlocks the 'door' for PPAR-alpha in the liver. There's also good evidence that the liver plays a key role in mediating cardiovascular risk through the secretion of multiple proteins associated with inflammation. In these mice we found that when too much fat got into the liver, there was excessive inflammation."
The team is now investigating which fats can be given to activate the PPAR-alpha pathway. Dr Semenkovich suggests that dieters who want to lose fat stored in peripheral tissues could consume small amounts of fats, such as fish oils, that might activate fat-burning pathways through the liver.
Not long ago, low-fat diet gurus were trying to terrorize people into reducing all fat consumption. Now that we have witnessed the epidemic of obesity that followed, we know better. Healthy fats help keep us slender! They also help protect against atherosclerosis, cancer, diabetes, autoimmune diseases, and various other degenerative disorders.
Through their impact on important metabolic enzymes, healthy fats increase the synthesis of beneficial prostaglandins E1 and E3 while decreasing the levels of inflammatory prostaglandin E2; they also modify cell membrane composition and fluidity. Hence, improved blood flow and tissue oxygenation, higher metabolic rate, improved insulin sensitivity, immune enhancement, more muscle and bone formation, better brain function, and faster nerve impulse conductance result, to mention just a few of the major benefits.
Thus, while in the 1970s and 1980s dietary fat was demonized and presented as being a problem, we are beginning to see various kinds of healthy fat as part of the solution.
An article in The American Journal of Clinical Nutrition described a study of dietary fish (Mori et. al. 1999). Overweight patients being treated for hypertension were randomly assigned to a daily fish-containing meal (3.65 g of omega-3 fatty acids); a weight-loss regimen; the two regimens combined; or a control group for 16 weeks. Fasting triglycerides fell 29% with fish consumption and 26% with weight loss. The fish plus weight-loss regimen group showed the greatest improvement in lipids: triglycerides decreased by 38% and HDL cholesterol increased by 24% compared with the control group. The authors concluded that adding a daily fish meal into a weight-loss regimen was more effective than either measure alone at improving glucose-insulin metabolism and dyslipidemia (Mori et. al. 1999).
Super EPA/DHA with Sesame Lignans & Olive Fruit Extract is from a new source of high quality fish oil with a unique 35%/25% ratio of EPA/DHA. The premium fish oil in Super EPA/DHA with Sesame Lignans & Olive Fruit Extract has been tested for pollutants including dioxins, furans, PCBs and heavy metals.
Super EPA/DHA now has the nutrient powerhouses of sesame lignans and fortified extra virgin olive oil. To get this level of nutrients found in these high oils would require excessive consumption of the native oils adding many calories to the daily diet.
Polyphen-Oil™ Olive Fruit Extract is a proprietary, fortified extra virgin olive oil complex developed by Life Extension. The naturally occurring polyphenol antioxidants are typically lost in olive juice discarded during olive oil pressing. Polyphen-Oil tm is highly enriched oil with olive juice extract standardized with these naturally occurring antioxidants.
In a study presented at the Experimental Biology 2002 meeting, CLA alone was shown to cause a substantial decrease in fat mass, and for those who received CLA plus guarana, both adipocyte (fat cell) size and number were decreased by 50%. As an added benefit, sesame lignans have been shown to further increase the burning of fat by stimulating fatty acid oxidation in the liver. As with any fatty acid, CLA can be oxidized by free radicals once it has been ingested. Sesame lignans help prevent the oxidation of CLA, providing health benefits without negative impact.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
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