Trial finds improved insulin sensitivity and blood glucose levels in overweight diabetics given EPA
Tuesday, August 6, 2013. The results of a double-blinded trial published in the July 2013 issue of Singapore Medical Journal show positive effects for the omega-3 fatty acid eicosapentaenoic acid (EPA) in overweight type 2 diabetics.
Mahmoud Djalali and his associates at Tehran University of Medical Sciences randomized 26 men and 41 women with diabetes to receive 2000 milligrams EPA or a corn oil placebo for twelve weeks. Blood samples collected before and after treatment were analyzed for hemoglobin A1c (HbA1c, a marker of long term glucose control), fasting plasma glucose and fasting serum insulin.
While plasma glucose, HbA1c, and serum insulin levels had increased by 4%, 3% and 4% in the control group by the end of the study, they declined by 11%, 8% and 3%, respectively, in those who received EPA. Insulin resistance also improved among those who received EPA. The authors note that, in contrast with the findings of other studies with shorter durations, the current study's length could account for the improvement observed in HbA1c, which represents average glucose concentration over the previous months.
In their discussion of the findings, the authors remark that omega-3 fatty acids' anti-inflammatory property could be one mechanism involved in their ability to improve insulin resistance. They note that omega-3 increases the fluidity of skeletal muscle membrane, resulting in improved glucose uptake. Furthermore, genes associated with insulin resistance could be positively affected by omega-3 fatty acids. They recommend additional clinical studies to help further understand the beneficial mechanisms of EPA in type 2 diabetic patients.
A presentation at the 2013 Institute of Food Technologists Annual Meeting & Expo, held in Chicago July 13-16, 2013, revealed a profound lack of omega-3 polyunsaturated fatty acids in the standard North American diet, despite what is known of the fatty acids' benefits. Physicians and their patients are being made increasingly aware of the role of omega-3 fatty acids in the prevention or reduction of inflammatory disorders and cardiovascular disease, among other conditions. However, the eating habits of most Americans still have a lot catching up to do.
Nutritional researcher Bruce J. Holub, PhD, who is a professor emeritus at the University of Guelph in Ontario, along with Alex Richardson, PhD, of the Centre for Evidence-Based Intervention at the University of Oxford in England attribute the widespread omega-3 deficiency to diets that provide little in the way of fish or seafood, which are the best food sources of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The average North American diet provides 200 milligrams EPA and/or DHA per day, which falls short of the American Heart Association's recommendation of 500 milligrams per day for healthy adults and 900 milligrams per day (which can be provided by one omega-3 supplement) for those with cardiovascular disease. For children, Dr Richardson suggests 500 milligrams omega-3 fatty acids per day, and for pregnant women, he recommends one gram.
"Physical risks to children from a nutritionally poor diet are now acknowledged, but the damage being done to their behavior, their learning abilities and mood is not," he stated. "I applaud any attempts (to recommend and encourage supplements) in the diets of mothers and women of childbearing age. It's never too late."
Life Extension Mix™ contains unique vegetable, fruit, botanical extracts, amino acids, vitamins, and minerals. This state-of-the-art multinutrient formula has been updated numerous times since its launch in 1983. The Life Extension Mix™ formula is fortified with botanical extracts that help maintain healthy cellular functions. Consumption of these types of botanical extracts is being recommended based on research emanating from the world's most prestigious medical centers. Life Extension Mix™ formula also contains a cutting-edge chromium complex to help maintain healthy glucose metabolism in those within normal range, a breakthrough antioxidant that helps support night vision, and a lemon-based folate in an amount that makes your personal dosing easier.
The formulation that already provides a broad spectrum of botanical extracts now also contains trans-pterostilbene. This compound, found naturally in blueberries and grapes, has been shown to have beneficial anti-aging effects on gene expression and to promote healthy cognitive function.
Many Americans do not obtain adequate amounts of magnesium in their diets. Magnesium is one of the body's most important minerals. It is required as a cofactor in hundreds of enzymatic processes within cells. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, promotes healthy cardiovascular function, supports a healthy immune system, and keeps bones strong. Magnesium also helps maintain blood sugar and blood pressure levels already within normal range, and it is known to be involved in energy metabolism and protein synthesis.
Magnesium positively influences the bone mineral matrix and its ability to metabolize minerals needed for repair and rebuilding. Scientific literature documents the need for a wide range of minerals, including calcium and magnesium, that are vital to maintaining strong, healthy bones.
Magnesium Caps provides one of the highest concentrations of elemental magnesium per capsule available on the market.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.