Vitamin D supplementation linked to better glycemic control
Saturday, November 11, 2017
The September 1, 2017 issue of The Journal of Clinical Endocrinology & Metabolism published the results of a meta-analysis that adds evidence to an association between better glycemic control among diabetics and higher vitamin D levels resulting from supplementation.
The meta-analysis included 24 controlled trials that included a total 1,528 individuals with type 2 diabetes who received a placebo or vitamin D with or without calcium for at least two months. Serum 25-hydroxyvitamin D levels and at least one measure of glycemic control, including hemoglobin A1c, (HbA1c, a marker of long term glucose control), fasting plasma glucose and HOMA-IR (which assess insulin resistance), were measured at the beginning and end of each trial.
All but one trial found a significant increase in serum vitamin D among those who received the vitamin. Supplementation with 4,200 international units (IU) vitamin D per day was associated with an average increase in serum 25-hydroxyvitamin D levels of 17 nanograms per milliliter (ng/mL). Hemoglobin A1c levels declined by an average of 0.3% in vitamin D supplemented participants. The addition of calcium to vitamin D was associated with an even greater decline.
Among participants who received vitamin D, fasting plasma glucose decreased by an average of 4.9 milligrams per deciliter (mg/dL). Insulin resistance also improved in vitamin D-supplemented participants. The authors suggest that glucose homeostasis is enabled by vitamin D supplementation and/or sun exposure that results in serum 25-hydroxyvitamin D concentrations of at least 40 ng/mL. (Life Extension suggests an optimal 25-hydroxyvitamin D range of 50-80 ng/mL.)
"Our meta-analysis found that vitamin D supplementation and subsequent increased serum 25-hydroxyvitamin D levels improved glucose control and insulin resistance in type 2 diabetic patients," the authors conclude. "Overall, vitamin D supplementation seems to be efficacious as an adjuvant treatment of diabetes-related glucose metabolism disorders. The results of the current meta-analysis suggest that a minimum dose of 4000 IU/day, which is equivalent to the tolerable upper intake level of vitamin D for adults, is required to have a protective effect on glucose homeostasis in type 2 diabetic patients."
When taking charge of your health, "winging it" is not ideal. You'll need to carefully choose the right supplements to provide your body with only the best! Not sure what supplements are right for you? Don't go it alone … our Supplement Guide is here to help.
Our Supplement Guide is an interactive tool where you give simple, confidential answers to pertinent questions that focus on your overall health and current lifestyle. You'll be guided through the entire process and at the end, have a personalized supplement regimen suggested to you via email. Our Supplement Guide is designed to help you steer your health in the right direction. Once you get started, you can always make adjustments to further optimize your nutritional supplement regimen. Visit our Supplement Guide today.
Life Extension Magazine® November 2017 Issue Now Online
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.