Meta-analysis affirms association between folic acid supplementation and lower risk of stroke in cardiovascular disease patients
February 27, 2018
A meta-analysis of 11 trials, published in the October 2017 issue of the American Journal of the Medical Sciences, found an association between supplementation with folic acid and a lower risk of stroke. Folic acid is the synthetic form of folate, an essential B vitamin. Both forms of the vitamin, along with vitamins B6 and B12, can help lower homocysteine, a potentially toxic amino acid which, when elevated, is associated with a greater risk of cardiovascular events.
"Folic acid and B vitamins play important roles in regulating homocysteine metabolism, and it is suggested that folic acid and vitamin B6 and B12 supplementation could reduce plasma homocysteine levels," write authors Tao Tian of Peking Union Medical College in Beijing and colleagues.
Dr Tian and associates selected 11 randomized trials involving a total of 65,790 cardiovascular disease patients for their analysis. Participants received folic acid (with or without other B vitamins) and control subjects received a placebo or usual care. Folic acid doses ranged from 0.5 to 5.0 milligrams folic acid per day for follow-up periods of 12 to 87 months, during which 2,826 stroke events occurred.
By pooling data from all participants, the researchers determined that those who received folic acid had a 10% lower risk of stroke compared to the control subjects. Among men and women who had at least a 25% reduction in homocysteine, supplementation with folic acid was associated with a 15% decrease in stroke risk. "Hyperhomocysteinemia has been identified as a modifiable, independent risk factor for cardiovascular disease, and is associated with an increased risk of stroke,” the authors write. “Considerable experimental evidence has been accumulated to support the role of homocysteine in promoting atherosclerosis, including inducing oxidative stress, enhancing inflammatory responses, and facilitating endothelial dysfunction."
They conclude that the meta-analysis showed that folic acid supplementation is effective among individuals with cardiovascular disease for stroke prevention.
When taking charge of your health, "winging it" is not ideal. You'll need to carefully choose the right supplements to provide your body with only the best! Not sure what supplements are right for you? Don't go it alone … our Supplement Guide is here to help.
Our Supplement Guide is an interactive tool where you give simple, confidential answers to pertinent questions that focus on your overall health and current lifestyle. You'll be guided through the entire process and at the end have a personalized supplement regimen suggested to you via email. Our Supplement Guide is designed to help you steer your health in the right direction. Once you get started, you can always make adjustments to further optimize your nutritional supplement regimen. Visit our Supplement Guide today.
Life Extension Magazine® March 2018 Issue Now Online
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.
If you are not 100% satisfied with any purchase made directly from Life Extension®, just return your purchase within 12 months of original purchase date and we will either replace the product for you, credit your original payment method or credit your Life Extension account for the full amount of the original purchase price (less shipping and handling).
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.