Life Extension Update
April 23, 2019
An article appearing on March 8, 2019, in Current Pharmaceutical Design reported findings from a meta-analysis of eight trials that found associations between vitamin D supplementation and improvement in glycemic control, inflammation and HDL cholesterol among those who received vitamin D supplements.
“Insulin resistance, dyslipidemia and chronic inflammation are important risk factors for cardiovascular disease (CVD),” wrote authors V. Ostadmohammadi and colleagues. “Hence, vitamin D supplementation might be an appropriate approach to decrease the complications of CVD.”
The researchers selected eight trials that included a total of 630 participants with cardiovascular disease for their analysis. Trials evaluated the effects of vitamin D supplementation on glycemic control, lipid profile and inflammation as indicated by levels of high sensitivity C-reactive protein (hs-CRP). Trial duration ranged from eight weeks to nine months.
A significant reduction in fasting plasma glucose and insulin concentrations as well as insulin resistance was revealed in association with vitamin D supplementation. In addition, insulin sensitivity and high-density lipoprotein (HDL) cholesterol improved in association with vitamin D. Furthermore, vitamin D was associated with a significant reduction in CRP, indicating lowered inflammation.
In their discussion, the authors observed that vitamin D helps protect against diabetes-related complications via antioxidant, anti-inflammatory and immunomodulatory effects, in addition to helping normalize the expression of proinflammatory markers involved in insulin resistance.
“To our best knowledge, this is the first meta-analysis of randomized controlled trials assessing the effect of vitamin D supplementation on glucose homeostasis parameters in patients with metabolic syndrome and related disorders,” the authors announced.
“This meta-analysis demonstrated some beneficial effects of vitamin D supplementation on improving glycemic control, HDL cholesterol and CRP levels among patients with cardiovascular disease,” they concluded.
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