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LE Accomplishments

Life Extension® has an extensive history of “firsts” in terms of recommending and identifying vitamins and supplements to American consumers while simultaneously alerting them to key industry issues:

Life Extension Recommended


Life Extension was the first to report that resveratrol (a substance found in grapes and other plants) can extend the life span of certain cells by as much as 70%.


The broad-spectrum anti-viral drug ribavirin to treat lethal viral infections. Twelve years later the FDA approved ribavirin as a treatment for Hepatitis C.


Life Extension was the first organization in the world to recommend the Japanese cardiac drug coenzyme Q10 (CoQ10) as an anti-aging nutrient. The use of high-dose CoQ10 in the United States is enabling people with congestive heart failure to resume normal lives because this nutrient significantly boosts cardiac energy output. High-dose CoQ10 also has been shown to significantly slow the progression of Parkinson’s disease.


The use of low-dose aspirin on a daily basis to reduce the risk of vascular disease. The majority of cardiologists in the United States now advocate low-dose aspirin to protect against a heart attack in cardiac patients.


B-complex vitamins to lower homocysteine blood levels. Homocysteine is now recognized as a risk factor for heart disease and stroke.


The hormone DHEA to slow aging. There are now hundreds of published papers substantiating DHEA’s youth promoting properties.


That healthy people consume high doses of antioxidant vitamins to maintain their health. Since then, thousands of studies have been published in prestigious journals documenting the role of antioxidants in protecting against disease.

Life Extension Identified


A novel compound called PQQ (pyrroloquinoline quinone) that has been shown to rejuvenate aging cells by promoting the growth of new mitochondria.


A form of Coenzyme Q10 (ubiquinol) that is vastly superior to commercial CoQ10 supplements in absorbing into the human bloodstream, reducing fatigue, and slowing age-related markers.


A novel fiber called glucomannan that supports healthy after-meal insulin release and postprandial (after meal) glucose (blood sugar) levels.


Methylselenocysteine, the form of selenium found naturally in garlic and broccoli that supports healthy cell growth and maturation.


High-dose carnosine to prevent the formation of advanced glycation end-products (AGEs), a key molecular substrate linked to premature aging and metabolic complications.


A unique, natural European therapy to support the liver.


A unique combination of natural ingredients used in Europe to support cognitive function.


Methylcobalamin, a natural form of vitamin B12 used in Japan to treat neurological disorders.


Urtica—dioica, a natural ingredient used in Europe for benign prostate enlargement.


S-adenosyl-methionine (SAMe), a natural ingredient largely unknown to the American public and healthcare professionals, yet used successfully in Europe for years in the context of depression, arthritis, and certain liver disorders. A Harvard study published more than a decade later (in 2010) supported the use of SAMe as a strategy to increase the response rate for conventional anti-depressant drugs by 105%.


The first comprehensive mail-order blood screening service that offered state-of-the-art tests for age-related diseases directly to the public.


Melatonin, a powerful natural antioxidant which may be used as a sleep aid and for anti-aging benefits.


Lycopene to support healthy cell growth and maturation.

A History of Consumer Advocacy


Life Extension reminded those Americans who live near a nuclear energy plant of the importance of having potassium iodide tablets on hand in case of a nuclear emergency, as it had first recommended nearly nine years prior in December 2002.


Life Extension identified how meso-zeaxanthin was critical for eye health given the epidemic of macular degeneration afflicting aging humans.


Life Extension alerted the public to the disease-causing toxins present in fish and provided a strategy for safely capturing the health-promoting benefits of fish oil.


Life Extension reported that optimal glucose levels should be lower than current guidelines to reduce heart attack risk by 40%. Soon after, national standards for the upper-scale limit of blood glucose were lowered, but still not to the lower levels recommended by Life Extension.


Life Extension advised customers to stock up on an anti-viral drug called Tamiflu® in case they were exposed to the common flu virus. Two years later, the world became so frightened about a potential SARS virus pandemic that Tamiflu® disappeared from pharmacy shelves worldwide.


Life Extension revealed how COX-2 inhibiting drugs could increase pro-inflammatory factors in the body, potentially leading to permanent joint damage and vascular disease. In 2004, one of these drugs (like Vioxx®) was taken off the market because of increased risks of heart attack in those who took it.


Life Extension warned how excess estrogen levels in aging men may be a causative factor in the development of prostate cancer and provided easy and safe methods to mitigate these effects.


Life Extension revealed the crucial importance of monitoring blood levels of fibrinogen, a risk factor for cardiovascular disease and stroke. Since then, numerous studies have confirmed that high levels of fibrinogen are indeed a heart attack and stroke risk factor, just like high cholesterol levels.


Life Extension warned that the commonly prescribed estrogen and synthetic progestin drugs could increase breast and ovarian cancer risk. Findings published years later confirmed these dangers. The natural hormone-balancing approaches long recommended by Life Extension have been shown to decrease common female cancers.


Life Extension® warned its customers against the intake of supplemental iron because of studies showing that excessive iron is associated with cancer. In 1988, New England Journal of Medicine published an article showing that men with high levels of iron had a 40% increase in their overall risk of cancer.