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Cancer Immunotherapy


AACR. DLBCL Responds Well to Anti-CD19 CAR Therapy. Cancer Discov. Mar 2017;7(3):241-242.

Abbas AK, Lichtman AH. Basic Immunology: Functions and Disorders of the Immune System. 3rd ed. Philadelphia, PA: Saunders Elsevier; 2009.

Abdul Hafid SR, Chakravarthi S, Nesaretnam K, Radhakrishnan AK. Tocotrienol-adjuvanted dendritic cells inhibit tumor growth and metastasis: a murine model of breast cancer. PloS one. 2013;8(9):e74753.

ACS. American Cancer Society. Does body weight affect cancer risk? Last updated 2/5/2016a. Accessed 7/19/2017.

ACS. American Cancer Society. Treatment & Support page. For people with weakened immune systems. Last updated 7/15/2015. Accessed 7/18/2017.

ACS. American Cancer Society. What is cancer immunotherapy? Last updated 8/8/2016b. Accessed 7/14/2017.

ACTIP. Animal Cell Technology Industrial Platform. Monoclonal Antibodies Approved by the EMA and FDA for Therapeutic Use (status 2013). 12/23/2013. Accessed 7/14/2017.

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Amgen. BiTE Antibody Constructs. Copyright 2017 by Amgen Inc. Accessed 8/9/2017

Anassi E, Ndefo UA. Sipuleucel-T (Provenge) Injection: The First Immunotherapy Agent (Vaccine) For Hormone-Refractory Prostate Cancer. Pharmacy and Therapeutics. 2011;36(4):197-202.

Andersen CJ, Murphy KE, Fernandez ML. Impact of Obesity and Metabolic Syndrome on Immunity. Adv Nutr. Jan 2016;7(1):66-75.

Andre FE, Safary A. Summary of clinical findings on Engerix-B, a genetically engineered yeast derived hepatitis B vaccine. Postgrad Med J. 1987;63 Suppl 2:169-177.

Andtbacka RH, Agarwala SS, Ollila DW, Hallmeyer S, Milhem M, Amatruda T, . . . Kaufman HL. Cutaneous head and neck melanoma in OPTiM, a randomized phase 3 trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor for the treatment of unresected stage IIIB/IIIC/IV melanoma. Head & neck. Dec 2016;38(12):1752-1758.

Andtbacka RH, Ross M, Puzanov I, Milhem M, Collichio F, Delman KA, . . . Kaufman HL. Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial. Annals of surgical oncology. Dec 2016;23(13):4169-4177.

Aranow C. Vitamin D and the immune system. Journal of investigative medicine: the official publication of the American Federation for Clinical Research. Aug 2011;59(6):881-886.

Armitage JO, Sidner RD. Antitumour effect of cimetidine. Lancet. Apr 21 1979;1(8121):882-883.

ASCO. American Society of Clinical Oncology. News Releases: Immunotherapy 2.0 Named Advance of the Year in ASCO's 12th Annual Cancer Progress Report. 2/1/2017. Accessed 8/10/2017.

AstraZeneca. Media page. Tremelimumab granted Orphan Drug Designation by US FDA for treatment of malignant mesothelioma. 4/15/2015. Accessed 8/21/2017.

Banday AH, Jeelani S, Hruby VJ. Cancer vaccine adjuvants--recent clinical progress and future perspectives. Immunopharmacology and immunotoxicology. Feb 2015;37(1):1-11.

Bandera Merchan B, Morcillo S, Martin-Nunez G, Tinahones FJ, Macias-Gonzalez M. The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences. The Journal of steroid biochemistry and molecular biology. Mar 2017;167:203-218.

Bang MH, Van Riep T, Thinh NT, Song le H, Dung TT, Van Truong L, . . . Ghoneum M. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer research. Dec 2010;30(12):5145-5151.

Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, . . . Meydani SN. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. The American journal of clinical nutrition. Mar 2016;103(3):942-951.

Barragan M, Good M, Kolls JK. Regulation of Dendritic Cell Function by Vitamin D. Nutrients. Sep 21 2015;7(9):8127-8151.

Barrett DM, Singh N, Porter DL, Grupp SA, June CH. Chimeric antigen receptor therapy for cancer. Annual review of medicine. 2014;65:333-347.

Bartlett DL, Liu Z, Sathaiah M, Ravindranathan R, Guo Z, He Y, Guo ZS. Oncolytic viruses as therapeutic cancer vaccines. Molecular cancer. Sep 11 2013;12(1):103.

Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. The American journal of physiology. Jun 1997;272(6 Pt 1):E1002-1007.

Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, . . . Bajorin DF. Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma. N Engl J Med. Mar 16 2017;376(11):1015-1026.

Berger GK, McBride A, Lawson S, Royball K, Yun S, Gee K, . . . Anwer F. Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review. Critical reviews in oncology/hematology. Jan 2017;109:42-50.

Bernstein V, Ellard S, Dent SF, Gelmon KA, Dhesy-Thind SK, Mates M, . . . Clemons M. Abstract CT131: A randomized (RCT) phase II study of oncolytic reovirus (pelareorep) plus standard weekly paclitaxel (P) as therapy for metastatic breast cancer (mBC). Cancer research. 2017.

Biothera Pharmaceuticals. Press Releases. Copyright 2016. Accessed 8/14/2017.

Bobadilla F, Rodriguez-Tirado C, Imarai M, Galotto MJ, Andersson R. Soluble beta-1,3/1,6-glucan in seaweed from the southern hemisphere and its immunomodulatory effect. Carbohydrate polymers. Jan 30 2013;92(1):241-248.

Bose S, Panda AK, Mukherjee S, Sa G. Curcumin and tumor immune-editing: resurrecting the immune system. Cell division. 2015;10:6.

Bouamama S, Merzouk H, Medjdoub A, Merzouk-Saidi A, Merzouk SA. Effects of exogenous vitamins A, C, and E and NADH supplementation on proliferation, cytokines release, and cell redox status of lymphocytes from healthy aged subjects. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. Jan 23 2017:1-9.

Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, . . . Jackson MJ. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. The American journal of clinical nutrition. Jul 2004;80(1):154-162.

Brown CE, Alizadeh D, Starr R, Weng L, Wagner JR, Naranjo A, . . . Badie B. Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy. N Engl J Med. Dec 29 2016;375(26):2561-2569.

Buque A, Bloy N, Aranda F, Cremer I, Eggermont A, Fridman WH, . . . Galluzzi L. Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy. Oncoimmunology. Jun 2016;5(6):e1149674.

Buras RR, Schumaker LM, Davoodi F, Brenner RV, Shabahang M, Nauta RJ, Evans SR. Vitamin D receptors in breast cancer cells. Breast Cancer Res Treat. 1994;31(2-3):191-202.

Cabrera AJ. Zinc, aging, and immunosenescence: an overview. Pathobiol Aging Age Relat Dis. 2015;5:25592.

Camisaschi C, Vallacchi V, Vergani E, Tazzari M, Ferro S, Tuccitto A, . . . Huber V. Targeting Immune Regulatory Networks to Counteract Immune Suppression in Cancer. Vaccines. Nov 04 2016;4(4).

Cao Dinh H, Beyer I, Mets T, Onyema OO, Njemini R, Renmans W, . . . Bautmans I. Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review. Calcified tissue international. Feb 2017;100(2):193-215.

Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. Journal of hematology & oncology. Jun 10 2009;2:25.

Chaplin DD. Overview of the immune response. The Journal of allergy and clinical immunology. Feb 2010;125(2 Suppl 2):S3-23.

Chen Q, Cheng M, Wang Z, Zhao S. The efficacy and safety of panitumumab plus irrinotecan-based chemotherapy in the treatment of metastatic colorectal cancer: A meta-analysis. Medicine. Dec 2016;95(50):e5284.

Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, . . . Zhou SF. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. International immunopharmacology. Mar 2006;6(3):499-508.

Cho YJ, Son HJ, Kim KS. A 14-week randomized, placebo-controlled, double-blind clinical trial to evaluate the efficacy and safety of ginseng polysaccharide (Y-75). J Transl Med. Oct 09 2014;12:283.

Choi JY, Paik DJ, Kwon DY, Park Y. Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-gamma activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. Nutr J. 2014;13:35.

Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, . . . Sedlak J. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. Mar 2013;62(3):437-445.

Chow LQ, Morishima C, Eaton KD, Baik CS, Goulart BH, Anderson LN, . . . Martins RG. Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN. Clinical cancer research: an official journal of the American Association for Cancer Research. Nov 03 2016.

Chu SL, Fu H, Yang JX, Liu GX, Dou P, Zhang L, . . . Wang XM. A randomized double-blind placebo-controlled study of Pu'er tea extract on the regulation of metabolic syndrome. Chin J Integr Med. Jul 2011;17(7):492-498.

Cipolla BG, Mandron E, Lefort JM, Coadou Y, Della Negra E, Corbel L, . . . Mottet N. Effect of Sulforaphane in Men with Biochemical Recurrence after Radical Prostatectomy. Cancer prevention research (Philadelphia, Pa.). Aug 2015;8(8):712-719.

Cluff CW. Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Advances in experimental medicine and biology. 2010;667:111-123.

Coquette A, Vray B, Vanderpas J. Role of vitamin E in the protection of the resident macrophage membrane against oxidative damage. Archives internationales de physiologie et de biochimie. Dec 1986;94(5):S29-34.

Costello C. An update on the role of daratumumab in the treatment of multiple myeloma. Therapeutic advances in hematology. Jan 2017;8(1):28-37.

Dang TO, Ogunniyi A, Barbee MS, Drilon A. Pembrolizumab for the treatment of PD-L1 positive advanced or metastatic non-small cell lung cancer. Expert review of anticancer therapy. 2016;16(1):13-20.

Das V, Kalita J, Pal M. Predictive and prognostic biomarkers in colorectal cancer: A systematic review of recent advances and challenges. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Mar 2017;87:8-19.

de Araujo AL, Silva LC, Fernandes JR, Matias Mde S, Boas LS, Machado CM, . . . Benard G. Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. Age (Dordrecht, Netherlands). Dec 2015;37(6):105.

De la Fuente M, Hernanz A, Guayerbas N, Victor VM, Arnalich F. Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research. Mar 2008;42(3):272-280.

Delves PJ. Merck Manual Professional Version [online]. Cellular Components of the Immune System. Last updated 1/2017. Accessed 8/4/2017.

Deva S, Jameson M. Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer. The Cochrane database of systematic reviews. Aug 15 2012(8):Cd007814.

DFCI. Dana-Farber Cancer Institute. What Is a Checkpoint Inhibitor? Immune Checkpoint Inhibitor Definition. Last updated 5/23/2017. Accessed 8/8/2017.

Diken M, Kranz LM, Kreiter S, Sahin U. mRNA: A Versatile Molecule for Cancer Vaccines. Current issues in molecular biology. 2017;22:113-128.

Ding J, Feng T, Ning Y, Li W, Wu Q, Qian K, . . . Qi C. beta-Glucan enhances cytotoxic T lymphocyte responses by activation of human monocyte-derived dendritic cells via the PI3K/AKT pathway. Human immunology. Mar 2015;76(2-3):146-154.

Dubensky TW, Jr., Reed SG. Adjuvants for cancer vaccines. Semin Immunol. Jun 2010;22(3):155-161.

Duffield-Lillico AJ, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, . . . Clark LC. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. May 2003;91(7):608-612.

Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ, . . . Murad MH. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. BMJ (Clinical research ed.). Dec 05 2016;355:i6188.

Dummer R, Hoeller C, Gruter IP, Michielin O. Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors. Cancer Immunol Immunother. Feb 25 2017.

Emilsson L, Holme O, Bretthauer M, Cook NR, Buring JE, Loberg M, . . . Kalager M. Systematic review with meta-analysis: the comparative effectiveness of aspirin vs. screening for colorectal cancer prevention. Alimentary pharmacology & therapeutics. Jan 2017;45(2):193-204.

Enioutina EY, Bareyan D, Daynes RA. TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. J Immunol. Apr 01 2009;182(7):4296-4305.

Enioutina EY, Bareyan D, Daynes RA. TLR ligands that stimulate the metabolism of vitamin D3 in activated murine dendritic cells can function as effective mucosal adjuvants to subcutaneously administered vaccines. Vaccine. Jan 30 2008;26(5):601-613.

FDA. U.S. Food and Drug Administration. FDA News Release: FDA approves first-of-its-kind product for the treatment of melanoma. Last updated 10/27/2015. Accessed 8/9/2017

Fiedler K, Lazzaro S, Lutz J, Rauch S, Heidenreich R. mRNA Cancer Vaccines. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 2016;209:61-85.

Finkelstein SE, Salenius S, Mantz CA, Shore ND, Fernandez EB, Shulman J, . . . Sims R. Combining immunotherapy and radiation for prostate cancer. Clinical genitourinary cancer. Feb 2015;13(1):1-9.

Floros T, Tarhini AA. Anticancer Cytokines: Biology and Clinical Effects of Interferon-alpha2, Interleukin (IL)-2, IL-15, IL-21, and IL-12. Seminars in oncology. Aug 2015;42(4):539-548.

Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V, . . . Small EJ. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer research. Jan 15 2009;69(2):609-615.

Fraker PJ, King LE, Laakko T, Vollmer TL. The dynamic link between the integrity of the immune system and zinc status. The Journal of nutrition. May 2000;130(5S Suppl):1399s-1406s.

Fritz H, Kennedy DA, Ishii M, Fergusson D, Fernandes R, Cooley K, Seely D. Polysaccharide K and Coriolus versicolor extracts for lung cancer: a systematic review. Integrative cancer therapies. May 2015;14(3):201-211.

Fukuhara H, Ino Y, Todo T. Oncolytic virus therapy: A new era of cancer treatment at dawn. Cancer science. Oct 2016;107(10):1373-1379.

Gabellier L, Cartron G. Obinutuzumab for relapsed or refractory indolent non-Hodgkin's lymphomas. Therapeutic advances in hematology. Apr 2016;7(2):85-93.

Gabrilovich D. Merck Manual Professional Version [online]. Host Response to Tumors. Last updated 2/2016. Accessed 8/4/2017.

Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, . . . Zhou S. Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. Journal of medicinal food. Summer 2005;8(2):159-168.

Garfall AL, Maus MV, Hwang WT, Lacey SF, Mahnke YD, Melenhorst JJ, . . . Stadtmauer EA. Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma. N Engl J Med. Sep 10 2015;373(11):1040-1047.

Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, . . . Koutsky LA. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med. May 10 2007;356(19):1928-1943.

Garnett-Benson C, Hodge JW, Gameiro SR. Combination regimens of radiation therapy and therapeutic cancer vaccines: mechanisms and opportunities. Seminars in radiation oncology. Jan 2015;25(1):46-53.

Garnock-Jones KP, Giuliano AR. Quadrivalent human papillomavirus (HPV) types 6, 11, 16, 18 vaccine: for the prevention of genital warts in males. Drugs. Mar 26 2011;71(5):591-602.

Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol. Dec 2004;56(12):1581-1588.

Ghoneum M, Agrawal S. Mgn-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. International journal of immunopathology and pharmacology. Oct-Dec 2014;27(4):523-530.

Gold Standard. Drug Monograph. Alemtuzumab. Copyright 2017a by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Aspirin, ASA. Copyright 2017b by Elsevier, Inc. Accessed 7/17/2017.

Gold Standard. Drug Monograph. Atezolizumab. Copyright 2017c by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Avelumab. Copyright 2017d by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Blinatumomab. Copyright 2017e by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Daratumumab. Copyright 2017f by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Elotuzumab. Copyright 2017g by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Nivolumab. Copyright 2017h by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Pembrolizumab. Copyright 2017i by Elsevier, Inc. Accessed 7/14/2017.

Gold Standard. Drug Monograph. Rituximab. Copyright 2017j by Elsevier, Inc. Accessed 8/8/2017.

Grattan BJ, Freake HC. Zinc and cancer: implications for LIV-1 in breast cancer. Nutrients. Jul 2012;4(7):648-675.

Gremel G, Lee RJ, Girotti MR, Mandal AK, Valpione S, Garner G, . . . Marais R. Distinct subclonal tumour responses to therapy revealed by circulating cell-free DNA. Ann Oncol. Oct 2016;27(10):1959-1965.

Guo C, Manjili MH, Subjeck JR, Sarkar D, Fisher PB, Wang XY. Therapeutic cancer vaccines: past, present, and future. Adv Cancer Res. 2013;119:421-475.

Gupta D, Lis CG. Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature. Journal of ovarian research. Oct 09 2009;2:13.

Haase H, Rink L. The immune system and the impact of zinc during aging. Immunity & ageing : I & A. 2009;6:9.

Hafid SR, Radhakrishnan AK, Nesaretnam K. Tocotrienols are good adjuvants for developing cancer vaccines. BMC cancer. Jan 06 2010;10:5.

Hammerstrom AE, Cauley DH, Atkinson BJ, Sharma P. Cancer Immunotherapy: Sipuleucel-T and Beyond. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2011;31(8):813-828.

Hanson MG, Ozenci V, Carlsten MC, Glimelius BL, Frodin JE, Masucci G, . . . Kiessling RV. A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients. Cancer Immunol Immunother. Jul 2007;56(7):973-984.

Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, . . . Dubin G. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet. Nov 13-19 2004;364(9447):1757-1765.

Henry NL, Hayes DF, Ramsey SD, Hortobagyi GN, Barlow WE, Gralow JR. Promoting quality and evidence-based care in early-stage breast cancer follow-up. J Natl Cancer Inst. Apr 2014;106(4):dju034.

Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, . . . Urba WJ. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. Aug 19 2010;363(8):711-723.

Hoffmann PR, Berry MJ. The influence of selenium on immune responses. Mol Nutr Food Res. Nov 2008;52(11):1273-1280.

Hoshimoto S, Faries MB, Morton DL, Shingai T, Kuo C, Wang HJ, . . . Hoon DS. Assessment of prognostic circulating tumor cells in a phase III trial of adjuvant immunotherapy after complete resection of stage IV melanoma. Ann Surg. Feb 2012;255(2):357-362.

Huang H, Ostroff GR, Lee CK, Specht CA, Levitz SM. Characterization and optimization of the glucan particle-based vaccine platform. Clinical and vaccine immunology: CVI. Oct 2013;20(10):1585-1591.

Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. Apr 01 2012;16(7):705-743.

Hughes DJ, Duarte-Salles T, Hybsier S, Trichopoulou A, Stepien M, Aleksandrova K, . . . Jenab M. Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. The American journal of clinical nutrition. Aug 2016;104(2):406-414.

Hughes DJ, Fedirko V, Jenab M, Schomburg L, Meplan C, Freisling H, . . . Hesketh JE. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International journal of cancer. Journal international du cancer. Mar 01 2015;136(5):1149-1161.

Huijskens MJ, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers BL, Tilanus MG, . . . Germeraad WT. Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy. May 2015;17(5):613-620.

Iv M, Telischak N, Feng D, Holdsworth SJ, Yeom KW, Daldrup-Link HE. Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors. Nanomedicine (London, England). 2015;10(6):993-1018.

Ivanov AP, Dragunsky EM, Chumakov KM. 1,25-dihydroxyvitamin d3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice. J Infect Dis. Feb 15 2006;193(4):598-600.

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Janeway CA, Travers P, Walport, et al. Principles of innate and adaptive immunity. In: Immunobiology: The Immune System in Health and Disease, 5th ed. New York: Garland Sciences; 2001b.

Janeway CA, Travers P, Walport M, et al. Generation of lymphocytes in bone marrow and thymus. In: Immunobiology: The Immune System in Health and Disease. 5th ed. New York: Garland Sciences; 2001c.

Jiang D, Wang X, Su Q, Jiang S, Yuan F, Zhang C, . . . Chen B. Milkvetch root improves immune function in patients with acute exacerbation of COPD. Bio-medical materials and engineering. 2015;26 Suppl 1:S2113-2121.

Jiang GM, Xie WY, Wang HS, Du J, Wu BP, Xu W, . . . Huang HJ. Curcumin combined with FAPalphac vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-alpha in melanoma. Oncotarget. Sep 22 2015;6(28):25932-25942.

Jiang T, Zhou C, Ren S. Role of IL-2 in cancer immunotherapy. Oncoimmunology. Jun 2016;5(6):e1163462.

Jiang Y, Tu PF. Analysis of chemical constituents in Cistanche species. Journal of chromatography. A. Mar 13 2009;1216(11):1970-1979.

Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. The Cochrane database of systematic reviews. Apr 05 2016;4:Cd007731.

Ju SA, Park SM, Lee YS, Bae JH, Yu R, An WG, . . . Kim BS. Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors. International journal of cancer. Journal international du cancer. Jun 01 2012;130(11):2618-2628.

Juergens RA, Zukotynski KA, Singnurkar A, Snider DP, Valliant JF, Gulenchyn KY. Imaging Biomarkers in Immunotherapy. Biomarkers in cancer. 2016;8(Suppl 2):1-13.

Kang S, Min H. Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System. J Ginseng Res. Oct 2012;36(4):354-368.

Kang TH, Lee JH, Song CK, Han HD, Shin BC, Pai SI, . . . Wu TC. Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer research. Jan 15 2007;67(2):802-811.

Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, . . . Schellhammer PF. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. Jul 29 2010;363(5):411-422.

Karbach J, Neumann A, Brand K, Wahle C, Siegel E, Maeurer M, . . . Jager E. Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity. Clinical cancer research: an official journal of the American Association for Cancer Research. Oct 01 2012;18(19):5449-5459.

Kim HJ, Barajas B, Wang M, Nel AE. Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. The Journal of allergy and clinical immunology. May 2008;121(5):1255-1261.e1257.

Kim HY, Kim JH, Yang SB, Hong SG, Lee SA, Hwang SJ, . . . Park MH. A polysaccharide extracted from rice bran fermented with Lentinus edodes enhances natural killer cell activity and exhibits anticancer effects. Journal of medicinal food. Mar 2007;10(1):25-31.

Kim JE, Cho HS, Yang HS, Jung DJ, Hong SW, Hung CF, . . . Kim D. Depletion of ascorbic acid impairs NK cell activity against ovarian cancer in a mouse model. Immunobiology. Sep 2012;217(9):873-881.

Kim R, Emi M, Tanabe K. Cancer immunoediting from immune surveillance to immune escape. Immunology. May 2007;121(1):1-14.

Kiper A, Yigitbasy O, Imamoglu A, Tuygun C, Turan C. The prognostic importance of prostate-specific antigen in monitoring patients undergoing maximum androgen blockage for metastatic prostate cancer. TheScientificWorldJournal. Jan 28 2005;5:118-124.

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