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Organ Transplantation


Afzali B et al. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol. 2007 Apr;148(1):32-46.

Ardalan MR et al. Black tea improves endothelial function in renal transplant recipients. Transplant Proc. 2007 May;39(4):1139-42.

Bauer S et al. Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients. Br J Clin Pharmacol. 2003 Feb;55(2):203-11.

Bharti AC et al. Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp Clin Transplant. 2010 Jun;8(2):161-71.

Biselli PM et al. Effect of folate, vitamin B6, and vitamin B12 intake and MTHFR C677T polymorphism on homocysteine concentrations of renal transplant recipients. Transplant Proc. 2007 Dec;39(10):3163-5.

Bucuvalas JC et al. Effect of treatment with prostaglandin E1 and N-acetylcysteine on pediatric liver transplant recipients: a single-center study. Pediatr Transplant. 2001 Aug;5(4):274-8.

Cainelli F and Vento S. Infections and solid organ transplant rejection: a cause-and-effect relationship? Lancet Infect Dis. 2002 Sep;2(9):539-49.

Chu Z et al. Influence of immunosuppressive drugs on the development of CD4(+)CD25(high) Foxp3(+) T cells in liver transplant recipients. Transplant Proc. 2010 Sep;42(7):2599-601.

Chueh SC et al. Curcumin enhances the immunosuppressive activity of cyclosporine in rat cardiac allografts and in mixed lymphocyte reactions. Transplant Proc. 2003 Jun;35(4):1603-5.

Connolly GM et al. Elevated homocysteine is a predictor of all-cause mortality in a prospective cohort of renal transplant recipients. Nephron Clin Pract. 2010;114(1):c5-11.

Cooper AL et al. Effect of dietary fish oil supplementation on fever and cytokine production in human volunteers. Clin Nutr. 1993 Dec;12(6):321-8.

de Arriba G et al. Vitamin E protects against the mitochondrial damage caused by cyclosporin A in LLC-PK1 cells. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):241-50.

de Mejia EG et al. Bioactive components of tea: cancer, inflammation and behavior. Brain Behav Immun. 2009 Aug;23(6):721-31.

de Nigris F et al. Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric Oxide. 2006 Nov;15(3):259-63.

Demirkiran A et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transpl. 2006 Feb;12(2):277-84.

Dlugosz A et al. Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients. Int Urol Nephrol. 2004;36(2):253-8.

Doutreleau S et al. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin Nutr. 2010 May;91(5):1261-7.

Duru M et al. Protective effects of N-acetylcysteine on cyclosporine-A-induced nephrotoxicity. Ren Fail. 2008;30(4):453-9.

Fang JC et al. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial. Lancet. 2002 Mar 30;359(9312):1108-13.

Flammer AJ et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation. 2007 Nov 20;116(21):2376-82.

Fleischhauer FJ et al. Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients. J Am Coll Cardiol. 1993 Mar 15;21(4):982-9.

Gupta BK et al. Magnesium repletion therapy improved lipid metabolism in hypomagnesemic renal transplant recipients: a pilot study. Transplantation. 1999 Jun 15;67(11):1485-7.

Hanidziar D and Koulmanda M. Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance. Curr Opin Organ Transplant. 2010 Aug;15(4):411-5.

Hermann M et al. Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. Int J Clin Pharmacol Ther. 2002 Oct;40(10):451-6.

Hollenbeak CS et al. The effect of surgical site infections on outcomes and resource utilization after liver transplantation. Surgery. 2001 Aug;130(2):388-95.

Holzmacher R et al. Low serum magnesium is associated with decreased graft survival in patients with chronic cyclosporin nephrotoxicity. Nephrol Dial Transplant. 2005 Jul;20(7):1456-62.

Homan van der Hide JJ et al. The effects of dietary supplementation with fish oil on renal function and the course of early postoperative rejection episodes in cyclosporine-treated renal transplant recipients. Transplantation. 1992 Aug;54(2):257-63.

Hosokawa Y et al. Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S151-8.

HRSA (Health Resources and Services Administration; U.S. Department of Health & Human Services). OPTN/SRTR Annual Report. (Data as of 2008) Accessed 10/14/2010.

Hsieh YH et al. Resveratrol attenuates ischemia - reperfusion-induced leukocyte - endothelial cell adhesive interactions and prolongs allograft survival across the MHC barrier. Circ J. 2007 Mar;71(3):423-8.

Hulten LM et al. Butylated hydroxytoluene and N-acetylcysteine attenuates tumor necrosis factor-alpha (TNF-alpha) secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro. Transplantation. 1998 Aug 15;66(3):364-9.

Hushmendy S et al. Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation. Nutr Res. 2009 Aug;29(8):568-78.

Jurrmann N et al. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr. 2005 Aug;135(8):1859-64.

Karlsen A et al. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur J Nutr. 2010 Sep;49(6):345-55.

Kim W et al. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J Nutr. 2009 May;139(5):1042-8.

Kimura A and Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010 Jul;40(7):1830-5.

Krauss-Etschmann S et al. Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol. 2008 Feb;121(2):464-470.e6.

Kun Z et al. Dietary omega-3 polyunsaturated fatty acids can inhibit expression of granzyme B, perforin, and cation-independent mannose 6-phosphate/insulin-like growth factor receptor in rat model of small bowel transplant chronic rejection. JPEN J Parenter Enteral Nutr. 2008 Jan-Feb;32(1):12-7.

Lake KD et al. Effect of oral vitamin E and C therapy on calcineurin inhibitor levels in heart transplant recipients. J Heart Lung Transplant. 2005 Aug;24(8):990-4.

Leiro JM et al. The anti-inflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-alpha (TNF-alpha) pre-mRNA splicing. Mol Immunol. 2010 Feb;47(5):1114-20.

Liu J et al. The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils. Cell Mol Immunol. 2005 Dec;2(6):455-60.

Ma HL et al. Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. Arthritis Rheum. 2010 Feb;62(2):430-40.

Malhotra P et al. Immunology of Transplant Rejection. Accessed 10/14/2010.

Manzoni J et al. Anti-inflammatory effect of parenteral fish oil lipid emulsion on human activated mononuclear leukocytes. Nutr Hosp. 2009 May-Jun;24(3):288-96.

Marcuzzi R et al. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Transplantation. 2003 May 15;75(9):1551-5.

Mazzaferro S et al. Ionised and total serum magnesium in renal transplant patients. J Nephrol. 2002 May-Jun;15(3):275-80.

McGuire SO et al. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutr Neurosci. 2006 Oct-Dec;9(5-6):251-8.

Morris ST et al. Endothelial dysfunction in renal transplant recipients maintained on cyclosporine. Kidney Int. 2000 Mar;57(3):1100-6.

Mostafavi-Pour Z et al. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res. 2008 Apr;38(4):385-92.

Muurling M et al. A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice. J Nutr. 2003 Nov;133(11):3350-5.

Neff GW et al. Consumption of dietary supplements in a liver transplant population. Liver Transpl. 2004 Jul;10(7):881-5.

Orea-Tejeda A et al. The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction. Cardiol J. 2010;17(5):464-70.

Ou ZJ et al. L-arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1131-9.

Pari L and Sivasankari R. Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol. 2008 Aug;22(4):395-401.

Park MK et al. Grape Seed Proanthocyanidin Extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol Lett. 2010 Oct 5.

Rayes N et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation. 2002 Jul 15;74(1):123-7.

Rayes N et al. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial. Am J Transplant. 2005 Jan;5(1):125-30.

Ruiz PA et al. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr. 2007 May;137(5):1208-15.

Rymarz A et al. Intravenous administration of N-acetylcysteine reduces plasma total homocysteine levels in renal transplant recipients. Ann Transplant. 2009 Oct-Dec;14(4):5-9.

Shakibaei M et al. Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci. 2007 Jan;1095:554-63.

Sikora E et al. Curcumin, inflammation, ageing and age-related diseases. Immun Ageing. 2010 Jan 17;7(1):1.

Singer P et al. Renal effects of parenteral fish oil administered to heart-beating organ donors and renal-transplant recipients: a tolerance study. Clin Nutr. 2004 Aug;23(4):597-603.

Spolidorio LC et al. Intermittent therapy with 1,25 vitamin D and calcitonin prevents cyclosporin-induced alveolar bone loss in rats. Calcif Tissue Int. 2010 Sep;87(3):236-45.

Tirkey N et al. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005 Oct 15;5:15.

van den Dorpel MA et al. Conversion from cyclosporine A to azathioprine treatment improves LDL oxidation in kidney transplant recipients. Kidney Int. 1997 May;51(5):1608-12.

Vandergheynst A et al. High prevalence of nocturnal arterial hypertension and non-dipping in lung transplant recipients. Acta Cardiol. 2010 Aug;65(4):395-400.

Vrochides D et al. Re-vascularization may not increase graft survival after hepatic artery thrombosis in liver transplant recipients. Hippokratia. 2010 Apr;14(2):115-8.

Walker LS. Natural Treg in autoimmune diabetes: all present and correct? Expert Opin Biol Ther. 2008 Nov;8(11):1691-703.

Wang J et al. Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. J Nutr Biochem. 2008 Jul;19(7):475-81.

Wheeler DS et al. Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J Nutr. 2004 May;134(5):1039-44.

Williams MJ et al. Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrol Dial Transplant. 2001 Jun;16(6):1251-5.

Winkelmayer WC et al. Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients. Kidney Int. 2005 May;67(5):1980-5.

Wu D et al. Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling. Free Radic Biol Med. 2009 Sep 1;47(5):636-43.

Wu SL et al. Apoptosis of lymphocytes in allograft in a rat liver transplantation model induced by resveratrol. Pharmacol Res. 2006 Jul;54(1):19-23.

Wung BS et al. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 2005 Dec 12;78(4):389-97.

Xie L et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol. 2009 May;9(5):575-81.

Yilmaz H et al. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol. 2007 Dec;62(6):579-85.

Ying B et al. Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Mol Biol Rep. 2009 Sep;36(7):1825-32.

Yu ES et al. Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells. Biochem Pharmacol. 2008 Jul 1;76(1):70-8.

Yu Y et al. [The effects of resveratrol on the activation, proliferation and cytokine expression of murine T lymphocytes] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005 Nov;21(6):697-9, 703.

Yuan GJ et al. Tea polyphenols inhibit expressions of iNOS and TNF-alpha and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int. 2006 May;5(2):262-7.

Zhang AB et al. Strong additive effect of calcitriol and cyclosporine A on lymphocyte proliferation in vitro and rat liver allotransplantations in vivo. Chin Med J (Engl). 2006 Dec 20;119(24):2090-5.

Zhang QY et al. [Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis] Zhonghua Nan Ke Xue. 2010a Jan;16(1):84-8.

Zhang W et al. Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance. J Immunol. 2010b Oct 15;185(8):4750-9.

Zittermann A et al. Calcitriol deficiency and 1-year mortality in cardiac transplant recipients. Transplantation. 2009 Jan 15;87(1):118-24.